@article {McMahan10.1212 / WNL。0000000000207339,作者={辛西娅·麦克马汉和德文郡k·迪特里希和伊丽莎白·f·霍恩和艾琳·凯利和卡特里娜Geannopoulos和彼得·斯莱姆Siyahhan Julnes和莉莲火腿和Ulisses Santamaria Chuen-Yen Lau天下吴Hsing-Chuan谢长廷和阿Ganesan凯瑟琳Berjohn萨阿德Kapetanovic和丹尼尔s帝国Govind Nair约瑟雪和布莱恩·k·阿甘和Avindra Nath和布莱恩·R·史密斯},title ={神经认知功能障碍与神经损伤在艾滋病毒感染者长期抗逆转录病毒疗法},elocation-id = {10.1212 / WNL。={2023}0000000000207339},年,doi = {10.1212 / WNL。出版商0000000000207339}= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘= {BackgroundNeurologic结果HIV携带者(PWH)在长时间的首页抗逆转录病毒疗法(ART)都是没有完全理解和潜在的病理生理学尚不清楚。为了解决这个问题,我们建立了一个群这样的个人和他们阴性对照相比使用小说匹配技术。两组进行了广泛的认知测试,评估精神措施,MRI和脑脊液(CSF)分析。MethodsParticipants接受全面的神经心理学(NP)测试和完成标准化的问卷测量抑郁症状,对自己的功能,日常生活活动作为一项观察性研究的一部分。脑部核磁共振和腰椎穿刺是可选的。腥红的确切匹配(CEM)被用来减少在年龄和性别差异,以及加权线性/逻辑回归模型被用来评估艾滋病对结果的影响。ResultsData对艺术进行了分析从155年PWH至少15年,100艾滋病毒阴性的控制。控制相比,PWH得分低关注的领域/工作记忆(PWH最小平方的意思(LSM) = 50.4和控制LSM = 53.1, p = 0.008)和运动功能(44.6 vs 47.7, p = 0.009),和一个测试信息的处理速度(符号搜索30.3和32.2,p = 0.003)。他们更可能自我报告在日常生活中更多的认知困难(p = 0.011)。 PWH also reported more depressive symptoms, general anxiety, and use of psychiatric medications (all with p\<0.05). PWH had reduced proportions of subcortical gray matter on MRI (β=-0.001, p\<0.001) and CSF showed elevated levels of neurofilament-light chain (664 vs. 529 pg/mL, p=0.01) and TNF-α (0.229 vs. 0.156 ng/mL, p=0.0008).ConclusionsPWH, despite effective ART for over a decade, displayed neurocognitive deficits and mood abnormalities. MRI and CSF analyses revealed reduced brain volume and signs of ongoing neuronal injury and neuroinflammation. As the already large proportion of virologically controlled PWH continues to grow, longitudinal studies should be conducted to elucidate the implications of cognitive, psychiatric, MRI, and CSF abnormalities in this group.}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/early/2023/04/27/WNL.0000000000207339}, eprint = {//www.ez-admanager.com/content/early/2023/04/27/WNL.0000000000207339.full.pdf}, journal = {Neurology} }