PT -期刊文章盟Tugce杜兰AU -萨拉Gaussoin AU -塞缪尔·洛克哈特盟梅丽莎梯级盟-马克Espeland AU -本杰明·威廉姆斯AU -蒂莫西·休斯盟苏珊娜工艺盟——邦妮(goldman Sachs)盟——詹姆斯·贝特曼TI -检查远距离卫生管理、临床前阿尔茨海默氏症认知复合tPACC,现场和远程的认知之间的可靠性测试(p6 - 6.002) - 10.1212 / WNL援助。0000000000202460 DP - 2023年4月25日TA -神经病首页学第六PG - 2302 - 100 IP - 17补充2 4099 - //www.ez-admanager.com/content/100/17_Supplement_2/2302.short 4100 - //www.ez-admanager.com/content/100/17_Supplement_2/2302.full所以Neurology2023 4月25日;100 AB -目的:评估tPACC分数从现场和远程的一致性测试。背景:临床试验景观在阿尔茨海默病(AD)和相关的痴呆症是集中在针对个人处于临床前阶段。临床前阿尔茨海默氏症认知综合现场管理(扣带皮层部位)开发捕捉微妙的淀粉样蛋白阳性个体认知能力的下降与淀粉样蛋白阴性。需要有一个便携式、复合测量敏感检测认知变化在认知正常(NC)和受损(MCI和痴呆)的参与者。设计/方法:我们检查了现场认知数据从662名成年人(70.2±8.1 y)的维克森林广告研究中心的临床核心,接受临床评价,认知测试,和裁定。扣带皮层部位面对面只计算使用RAVLT延迟回忆,数字符号编码(DSC),语义流畅性,延迟逐字工艺故事,MMSE总分使用基线数控参与者作为参考。tPACC使用测量,可以在现场和远程访问与修改的面对面扣带皮层部位;蒙特利尔认知评估(MoCA)是用于代替MMSE、DSC并没有包括在内。一个子集分析与扣带皮层部位面对面和tPACC远离一个试点研究了可靠性之间面对面的和远程测试。 We performed correlation analysis and generated Bland-Altman plots.Results: Of the 662 adults studied, 434 (66%) were female, 522 (79%) were White, 206 (34%) were APOE4 carriers, and mean education was 15.9±4.1 years. At baseline, there is a significant positive relationship between in-person tPACC and PACC (Overall group; r2=0.94, p=<0.0001, n=640). Although there is a good agreement in both subgroups (Impaired: r2=0.86, p=<0.0001, n=301 and NC: r2=0.90, p=<0.0001, n=328), tPACC overestimates cognitive performance compared to PACC for those with lower scores. We also found good agreement between in-person PACC and remote tPACC (r2=0.83, p=<0.0001, n=38).Conclusions: There is generally good agreement between tPACC and PACC for NC and impaired individuals.Disclosure: Miss Duran has nothing to disclose. The institution of Ms. Gaussoin has received research support from NIH. The institution of Dr. Lockhart has received research support from NIH. Dr. Rundle has nothing to disclose. The institution of Dr. Espeland has received research support from Alzheimer’s Association. The institution of Dr. Espeland has received research support from National Institutes of Health. Dr. Espeland has received personal compensation in the range of $500-$4,999 for serving as a Consultant with National Institutes of Health. Dr. Williams has nothing to disclose. Tim Hughes has nothing to disclose. Suzanne Craft has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Cognito Therapeutics. Suzanne Craft has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for T3D Therapeutics. Suzanne Craft has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Cyclerion Therapeutics. Suzanne Craft has received personal compensation in the range of $500-$4,999 for serving as a member, Board of Scientific Counselors with NIA. Bonnie Sachs has received research support from NIH. Bonnie Sachs has received research support from Alzheimer’s Association. The institution of Dr. Bateman has received research support from NIA.