% 0期刊文章%一个圣地亚哥Clocchiatti-Tuozzo % Cyprien河%一个维克多Torres-Lopez Daniela Renedo % %一个凯文Sheth山姆Payabvash % %圭多要求托马斯•吉尔% % T睡眠时间与临床沉默脑损伤在中年的人中风(p1 - 13.004) % D R 10.1212 / WNL 2023%。0000000000202523 % J首页神经病学% P V 100% N 17补充2% 2395% X目的:研究是否理想睡眠时间恶化神经成像大脑健康档案在中年的人中风。背景:证据表明,优化期间心血管健康的中年导致大脑健康。美国生活简单的7,心血管健康研究和公共卫生建设,最近添加的睡眠一个风险因素,成为生活必不可少的8 (LE8)。设计/方法:我们在英国生物库进行了横断面神经影像学分析。我们包括参与者没有中风/痴呆进行了脑磁共振研究。我们创建了一个6-category睡眠分数据小时的睡眠(最好更糟):7 - < 9 h;9 < 10 h;6 < 7 h;5 < 6 > = 10 h;4 < 5 h;和< 4 h。体积我们评估3神经影像学特征:白质高密度(自然对数转换),分数各向异性(FA)和平均扩散系数(MD)。 For FA and MD, we evaluated the first principal component of measurements obtained across 48 neuroanatomical regions.Results: Of 502,408 participants enrolled in the UKB, 39,937 (7.9%) stroke/dementia-free enrollees participated in the brain MRI study (mean age 55, 53% female). The distribution of sleep categories was: 1 (n=28,958, 72.51%), 2 (n=2060, 5.16%), 3 (n=7165, 17.94%), 4 (n=1,562, 3.91%), 5 (n=163, 0.41%) and 6 (n=29, 0.07%). In multivariable linear regression analyses, a higher (worse) sleep score was associated with larger WMH volume (beta 0.026, SE=0.0046; p<0.001) and worse FA profile (beta 0.003, SE=0.0008; p<0.001), with no association observed for MD (p=0.77). For FA, when evaluating the 48 neuroanatomical regions separately, the most compromised areas were the right cerebral peduncle (p<0.001) and left and right cerebellar peduncles (p<0.001).Conclusions: Among middle-aged participants enrolled in the UKB, suboptimal sleep duration was significantly associated with adverse neuroimaging brain health profiles. Sleep duration may thus determine brain health in middle-aged persons who have not developed clinically evident manifestations of poor brain health (stroke or dementia).Disclosure: Mr. Clocchiatti-Tuozzo has nothing to disclose. Dr. Rivier has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Pyxis Partners. Dr. Renedo has nothing to disclose. Mr. Torres-Lopez has nothing to disclose. Sam Payabvash has nothing to disclose. Dr. Sheth has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Ceribell. Dr. Sheth has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Zoll. Dr. Sheth has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for NControl. Dr. Sheth has received stock or an ownership interest from Astrocyte. Dr. Sheth has received stock or an ownership interest from Alva. The institution of Dr. Sheth has received research support from Biogen. The institution of Dr. Sheth has received research support from Novartis. The institution of Dr. Sheth has received research support from Bard. The institution of Dr. Sheth has received research support from Hyperfine. Dr. Sheth has received intellectual property interests from a discovery or technology relating to health care. Thomas Gill has nothing to disclose. The institution of Dr. Falcone has received research support from NIH. The institution of Dr. Falcone has received research support from AHA. %U