TY -的T1 CSF-In梯度丘脑和大脑皮层损伤的多发性硬化症:3 t磁化传递率神经学研究(S27.002) JF -乔-神经学做- 10.1212 / WNL。首页0000000000202930六世- 100 - 17补充2 SP - 2973 AU -玛蒂娜·鲁宾AU -伊丽莎白。帕加尼盟Loredana Storelli AU -亚历山德罗代表我非盟-保罗Preziosa AU -莫妮卡Margoni AU -玛丽亚罗卡盟马西莫菲利皮主持Y1 - 2023/04/25 UR - //www.ez-admanager.com/content/100/17_Supplement_2/2973.abstract N2 -目的:探讨MS患者的皮层和丘脑微观结构异首页常据进步距离CSF及其临床意义。背景:CSF-in梯度在皮层和丘脑损害已经建议在多发性硬化症(MS),可能由于CSF-mediated病理过程。然而,这种模式的并发损伤尚未探索体内和在大脑皮层和丘脑。设计/方法:大脑3 t-mri序列从52获得医学患者(33复发缓和(RR), 19进步[P]), 56健康对照组(HC)。从3 dt1-weighted序列,皮质层采样在25% -50% -75%深度从白质(WM)皮质接口(Freesurfer)和丘脑的同心乐队从ventricular-thalamus 1-2-3-voxels接口(内部实现方法)。群体间的比较(地铁)磁化传递率值,在皮层和丘脑的层和髓鞘形成指数与临床的相关性和结构措施评估使用线性混合模型和斯皮尔曼相关系数。结果:与HC相比,名RRMS和经前综合症患者显示显著降低地铁值在最肤浅的皮质层(名RRMS =−1.23%, p = 0.006,经前综合症=−1.70%,p = 0.002),没有差异。HC相比,名RRMS和经前综合症患者显示显著降低地铁值带离心室(名RRMS =−1.63%, p = 0.015,经前综合症=−3.62%,术中;0.001)。PMS显示也显著降低地铁在ventricle-closest乐队名RRMS相比(p = 0.022)和第二乐队相比,HC (−1.07%, p = 0.048)。降低地铁的价值观CSF-closest皮层和丘脑的层长有显著相关性疾病持续时间、高扩展残疾状态量表(eds)评分,更高的WM病变体积(r从0.45−−0.35,p≤0.011),低规范化大脑、丘脑和大脑皮层卷(r从0.42到0.56,p≤0.002)。结论:女士,临床相关CSF-in梯度损伤可以检测到3 t的皮层和丘脑,更大量的在丘脑和经前综合症。披露:鲁宾博士没有披露。伊丽莎白帕加尼没有披露。 Loredana Storelli has nothing to disclose. Alessandro Meani has nothing to disclose. Mr. Preziosa has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bristol Myers Squibb . Mr. Preziosa has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Sanofi Genzyme. Mr. Preziosa has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. Mr. Preziosa has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Roche. Mr. Preziosa has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Merck. Monica Margoni has received research support from MAGNIMS. Maria Assunta Rocca has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bayer, Biogen, Bristol Myers Squibb, Celgene, Genzyme, Merck Serono, Novartis, Roche, and Teva. The institution of Maria Assunta Rocca has received research support from Italian Ministry of Health, MS Society of Canada and Fondazione Italiana Sclerosi Multipla. Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Bayer, Biogen Idec, Merck-Serono, Novartis, Roche, Sanofi Genzyme, Takeda, and Teva Pharmaceutical Industries. Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Bayer, Biogen Idec, Merck-Serono, Novartis, Roche, Sanofi Genzyme, Takeda, and Teva Pharmaceutical Industries. Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Springer Nature. The institution of Dr. Filippi has received research support from Biogen Idec, Merck-Serono, Novartis, Roche, Teva Pharmaceutical Industries, Italian Ministry of Health, Fondazione Italiana Sclerosi Multipla, and ARiSLA (Fondazione Italiana di Ricerca per la SLA). ER -