@article {Singh2476作者= {Neha Atulkumar辛格和彼得·马丁和乔纳森Graff-Radford玛丽Machulda和密涅瓦Carrasquillo Nilufer谭和基思·约瑟夫和詹妮弗Whitwell}, title = {APOEɛ4影响内部和之间的网络功能连通性在典型的阿尔茨海默病(赛0 - 6.006)},体积={100},数量={17补充2},elocation-id = {2476} = {2023}, doi = {10.1212 / WNL。出版商0000000000202583}= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的:评估功能连通性后皮质萎缩(PCA)和logopenic进行性失语(LPA首页)和评估和网络功能连通性的基础上不同的载脂蛋白E (APOE)ɛ4地位。背景:APOEɛ4影响萎缩和τ沉积在非典型{\ textquoteright}的老年痴呆症患者(广告),与APOEɛ4运营商内侧颞参与更大的倾向。这就提出了问题APOE基因型是否会影响记忆的网络连接,网络主要由内侧颞结构。设计/方法:一百年四十amyloid-positive PCA (n = 58)和LPA (n = 82)招募的患者神经退行性研究小组,并进行了结构和静息状态功能磁共振成像。空间数据预处理进行了分析探索默认模式网络(静),突出,语言、视觉和记忆网络,使用的方法在康涅狄格州的工具箱。贝叶斯分层线性模型(BHLM)调整年龄和性别的影响评估APOEɛ4内和网络连通性。结果:我们发现减少网络连通性的记忆和语言网络LPA, PCA显著增加网络连接,在APOEɛ4运营商而非承运人。APOEɛ4并不影响PCA的记忆影响网络的连通性。网络分析显示的证据,静的连通性两组降低,减少DMN-to-salience和DMN-to-language PCA APOEɛ4运营商网络连接,并降低DMN-to-visual LPA APOEɛ4运营商的网络连接。此外,我们发现减少连接APOEɛ4 visual-to-language和visual-to-salience网络的航空公司而非承运人的PCA和LPA。网络级和voxel-level发现同意BHLM发现,专门显示减少的影响网络的连通性在LPA APOEɛ4记忆网络运营商。结论:APOE基因型影响大脑连接,内和网络之间,在非典型广告变体。 However, there was evidence that the modulatory effects of APOE differ across phenotype.Disclosure: Dr. Singh has nothing to disclose. Mr. Martin has nothing to disclose. Dr. Graff-Radford has received personal compensation for serving as an employee of Mayo Clinic. Dr. Graff-Radford has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for NINDS/NIH. Dr. Graff-Radford has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for American Academy of Neurology. The institution of Dr. Graff-Radford has received research support from NIH. The institution of Dr. Machulda has received research support from NIH. Minerva Carrasquillo has nothing to disclose. The institution of Dr. Taner has received research support from NIH. Dr. Josephs has nothing to disclose. Dr. Whitwell has nothing to disclose.}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/100/17_Supplement_2/2476}, eprint = {//www.ez-admanager.com/content}, journal = {Neurology} }