RT期刊文章SR电子T1结构和功能连接体改变在国王的阶段肌萎缩性脊髓侧索硬化症(S33.006)摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP 3984 10.1212 / WNL。首页0000000000203660签证官100 17补充2 A1 Edoardo卢卡雷利A1阿尔玛Ghirelli A1西尔维亚Basaia A1卡米拉Cividini A1尼洛莉娃A1托马索·鲁索A1 Elisa Canu A1 Veronica Castelnovo A1马西莫菲利皮主持A1 Federica Agosta年2023 UL //www.ez-admanager.com/content/100/17_Supplement_2/3984.abstract AB目的:首页探索内部结构和功能连接的重组和大脑网络潜在的临床推广肌萎缩性脊髓侧索硬化症(ALS),所述由国王的分期系统,为了显示目标,连续措施镜像疾病进展。背景:定量和可再生的标记的识别ALS疾病进展的研究设计是至关重要的,包含同质病人军团进入临床试验,因为目前还没有验证对ALS疾病的阶段生物标志物。设计/方法:104 ALS患者和61岁,sex-matched健康对照组进行临床和脑磁共振成像(MRI) 3 t扫描仪。患者分为四组,根据国王的分期系统。没有病人共病额颞叶痴呆。值在结构和功能上的连接和不同解剖大脑区域之间获得使用扩散张量和静息状态功能磁共振成像数据,分别。比较组间进行使用年龄,sex-adjusted方差分析模型。使用皮尔逊系数的相关性进行了测试。结果:与控制相比,明显,逐步减少在大脑结构连接节点的感觉运动网络的ALS患者的观察在国王的阶段2、3和4 (p < 0.006)。患者在阶段3和4显示重大损失额和感觉运动区域之间的结构连接(p = 0.001)。功能连通性的重要破坏额颞叶区域内被发现只有在第四阶段(p = 0.025)。 Sensorimotor structural connectivity showed a strong correlation with ALSFRS-r scores (r=0.31, p=0.001).Conclusions: Brain MRI allows to demonstrate and quantify increasing disruption of structural connectivity involving the sensorimotor and frontal networks in ALS, mirroring disease progression. Frontotemporal functional disconnection seems to characterize only advanced disease stages. Our findings demonstrate the utility of MRI connectomics to stratify patients and stage brain pathology in ALS in a reproducible way, which mirrors clinical progression.Disclosure: Dr. Spinelli has nothing to disclose. Miss Ghirelli has nothing to disclose. Silvia Basaia has nothing to disclose. Ms. Cividini has nothing to disclose. Nilo Riva has nothing to disclose. Dr. Russo has nothing to disclose. The institution of Elisa Canu has received research support from Italian Ministry of Health . Dr. Castelnovo has nothing to disclose. Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Bayer, Biogen Idec, Merck-Serono, Novartis, Roche, Sanofi Genzyme, Takeda, and Teva Pharmaceutical Industries. Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Bayer, Biogen Idec, Merck-Serono, Novartis, Roche, Sanofi Genzyme, Takeda, and Teva Pharmaceutical Industries. Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Springer Nature. The institution of Dr. Filippi has received research support from Biogen Idec, Merck-Serono, Novartis, Roche, Teva Pharmaceutical Industries, Italian Ministry of Health, Fondazione Italiana Sclerosi Multipla, and ARiSLA (Fondazione Italiana di Ricerca per la SLA). Federica Agosta has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Philips. Federica Agosta has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier INC.