@article {Spinelli3984作者= {Edoardo卢卡雷利和阿尔玛Ghirelli西尔维亚Basaia和卡米拉Cividini和尼洛莉娃和托马索·鲁索Elisa Canu Veronica Castelnovo和马西莫菲利皮主持Federica Agosta}, title ={结构和功能连接体改变在国王{\ textquoteright}年代阶段肌萎缩性脊髓侧索硬化症(S33.006)},体积={100},数量={17补充2},elocation-id = {3984} = {2023}, doi = {10.1212 / WNL。出版商0000000000203660}= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的:探讨内部结构和功能连接的重组和大脑网络潜在的临床推广肌萎缩性脊髓侧索硬化首页症(ALS),所述由国王{\ textquoteright}年代分期系统,为了显示目标,连续措施镜像疾病进展。背景:定量和可再生的标记的识别ALS疾病进展的研究设计是至关重要的,包含同质病人军团进入临床试验,因为目前还没有验证对ALS疾病的阶段生物标志物。设计/方法:104 ALS患者和61岁,sex-matched健康对照组进行临床和脑磁共振成像(MRI) 3 t扫描仪。患者被分为四组,根据王{\ textquoteright}年代分期系统。没有病人共病额颞叶痴呆。值在结构和功能上的连接和不同解剖大脑区域之间获得使用扩散张量和静息状态功能磁共振成像数据,分别。比较组间进行使用年龄,sex-adjusted方差分析模型。使用皮尔逊相关性测试{\ textquoteright}年代系数。结果:与控制相比,明显,逐步减少在大脑结构连接节点的感觉运动网络的ALS患者的观察在国王{\ textquoteright} s阶段2、3和4 (p < 0.006)。患者在阶段3和4显示重大损失额和感觉运动区域之间的结构连接(p = 0.001)。功能连通性的重要破坏额颞叶区域内被发现只有在第四阶段(p = 0.025)。感觉运动结构连通性表现出很强的相关性与ALSFRS-r分数(r = 0.31, p = 0.001)。Conclusions: Brain MRI allows to demonstrate and quantify increasing disruption of structural connectivity involving the sensorimotor and frontal networks in ALS, mirroring disease progression. Frontotemporal functional disconnection seems to characterize only advanced disease stages. Our findings demonstrate the utility of MRI connectomics to stratify patients and stage brain pathology in ALS in a reproducible way, which mirrors clinical progression.Disclosure: Dr. Spinelli has nothing to disclose. Miss Ghirelli has nothing to disclose. Silvia Basaia has nothing to disclose. Ms. Cividini has nothing to disclose. Nilo Riva has nothing to disclose. Dr. Russo has nothing to disclose. The institution of Elisa Canu has received research support from Italian Ministry of Health . Dr. Castelnovo has nothing to disclose. Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Bayer, Biogen Idec, Merck-Serono, Novartis, Roche, Sanofi Genzyme, Takeda, and Teva Pharmaceutical Industries. Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Bayer, Biogen Idec, Merck-Serono, Novartis, Roche, Sanofi Genzyme, Takeda, and Teva Pharmaceutical Industries. Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Springer Nature. The institution of Dr. Filippi has received research support from Biogen Idec, Merck-Serono, Novartis, Roche, Teva Pharmaceutical Industries, Italian Ministry of Health, Fondazione Italiana Sclerosi Multipla, and ARiSLA (Fondazione Italiana di Ricerca per la SLA). Federica Agosta has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Philips. Federica Agosta has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier INC.}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/100/17_Supplement_2/3984}, eprint = {//www.ez-admanager.com/content}, journal = {Neurology} }