% 0期刊文章% Federica Agosta %一个卡米拉Cividini %西尔维亚Basaia % Edoardo卢卡雷利% Veronica Castelnovo % Michela Leocadi % Elisa Canu %马西莫菲利皮主持% T年龄相关漏洞人类大脑的连接体(赛0 - 6.008)% D R 10.1212 / WNL 2023%。0000000000203506 % J首页神经病学% P V 100% N 17补充2% 3759% X目的:评估老龄化如何影响人类大脑的功能连接的关键区域的连接体(即。,中心),这代表潜在漏洞站的老化,以及这些影响是否影响整个大脑的功能和结构都发生了变化。背景:多因子的模型集成老化大脑变量在多个尺度的调查及其与神经退化的关系。设计/方法:我们招收了128名没有参与者的认知,根据年龄分为两组:50个年轻人(≤35岁)和78名老年人(> 35岁)。在进入研究,两组接受脑部核磁共振成像扫描。我们结合的信息功能连接体脆弱性,通过一个创新的图分析方法研究(逐步功能连通性),老化的大脑皮质萎缩。结果:第一,研究拓扑功能最佳的健康状况(即网络组织。年轻的成年人),我们观察到fronto-temporo-parietal中心显示与自己和彼此间的直接功能连通性,而枕中心显示直接枕区域和感觉运动区域内功能连通性。造型皮质厚度变化的寿命,我们观察到fronto-temporo-parietal中心是改变了大部分的大脑区域,而枕中心显示跨年龄相当幸免皮质厚度。最后,皮质区域高度功能与fronto-temporo-parietal中心健康成人的特点是沿寿命最大的皮质萎缩。结论:我们的研究结果揭示了一个重要的角色塑造的中心连接体拓扑和几何的生物损伤的积累和分布与老化萎缩,支持假设中心功能连通性重组出现管理区域特定大脑区域的结构改变。披露:Federica Agosta已收到个人薪酬在500 - 4999美元的范围在飞利浦的演讲人。Federica Agosta已收到个人薪酬在500 - 4999美元的范围作为一个编辑,副主编或编辑顾问委员会成员,爱思唯尔公司Cividini女士没有披露。西尔维亚Basaia没有披露。 Dr. Spinelli has nothing to disclose. Dr. Castelnovo has nothing to disclose. Dr. Leocadi has nothing to disclose. The institution of Elisa Canu has received research support from Italian Ministry of Health . Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Bayer, Biogen Idec, Merck-Serono, Novartis, Roche, Sanofi Genzyme, Takeda, and Teva Pharmaceutical Industries. Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Bayer, Biogen Idec, Merck-Serono, Novartis, Roche, Sanofi Genzyme, Takeda, and Teva Pharmaceutical Industries. Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Springer Nature. The institution of Dr. Filippi has received research support from Biogen Idec, Merck-Serono, Novartis, Roche, Teva Pharmaceutical Industries, Italian Ministry of Health, Fondazione Italiana Sclerosi Multipla, and ARiSLA (Fondazione Italiana di Ricerca per la SLA). %U