TY - T1的睡眠模式和急性中风的风险:INTERSTROKE国际病例对照研究的结果JF -神经学乔-神经- 10.1212 / WNL。首页0000000000207249 SP - 10.1212 / WNL。0000000000207249 AU -克里斯汀艾琳Mc凯西的AU - Salim Yusuf AU -康纳法官AU -阿尔贝托Alvarez-Iglesias AU -格雷姆j .纸巾盟Shahram Oveisgharan AU - Albertino Damasceno AU -克林根贝格赫勒球队盟安妮卡工厂的非盟-阿尔瓦罗·Avezum盟会长Patricio Lopez-Jaramillo AU -丹尼斯Xavier AU - Xingyu王盟Sumathy Rangarajan周二AU -马丁·奥唐纳Y1 - 2023/04/05 UR - //www.ez-admanager.com/content/early/2023/04/05/WNL.0000000000207249.abstract N2 -背景和目的:睡眠障碍是常见的症状,可能代表重要的可改变的中风危险因素。首页我们评估之间的联系的睡眠障碍症状和急性中风的风险在国际设置。方法:INTERSTROKE是国际第一急性中风患者的病例对照研究和控制相应的年龄(+ / - 5年)和性。睡眠症状前一个月通过问卷进行评估。条件逻辑回归估计睡眠障碍症状和急性中风之间的关系,表示为优势比和95%置信区间。的主要模型调整年龄、职业、婚姻状况和modified-Rankin规模在基线,后续模型调整潜在介质(行为/疾病危险因素)。结果:总体而言,4496年与参与者包括了1799个参与者经历了缺血性中风和439个颅内出血。Short sleep (<5hrs: 3.15, 2.09-4.76), long sleep (>9hr: 2.67, 1.89-3.78), impaired quality (1.52, 1.32-1.75), difficulty getting to sleep (1.32, 1.13-1.55) or maintaining sleep (1.33, 1.15-1.53), unplanned napping (1.59, 1.31-1.92), prolonged napping (>1hr: 1.88, 1.49-2.38), snoring (1.91, 1.62-2.24), snorting (2.64, 2.17-3.20) and breathing cessation (2.87, 2.28-2.60) were all significantly associated with increased odds of acute stroke in the primary model. A derived Obstructive Sleep Apnoea (OSA) score of 2-3 (2.67, 2.25-3.15) and cumulative sleep symptoms (>5: 5.06, 3.67-6.97) were also associated with a significantly increased odds of acute stroke, with the latter showing a graded association. Following extensive adjustment, significance was maintained for the majority of symptoms (not difficulty getting to/maintaining sleep and unplanned napping), with similar findings for stroke subtypes.Discussion: We found that sleep disturbance symptoms were common, and associated with a graded increased risk of stroke. These symptoms may be a marker of increased individual risk, or represent independent risk factors. Future clinical trials are warranted to determine the efficacy of sleep interventions in stroke prevention. ER -