PT -期刊文章盟Christine艾琳Mc凯西的非盟- Salim Yusuf AU -康纳法官AU -阿尔贝托Alvarez-Iglesias AU -格雷姆j .纸巾盟Shahram Oveisgharan AU - Albertino Damasceno AU -赫勒克林根贝格球队AU -安妮卡工厂的非盟-阿尔瓦罗·Avezum盟会长Patricio Lopez-Jaramillo AU -丹尼斯·泽维尔盟Xingyu王盟Sumathy Rangarajan周二AU -马丁·奥唐纳TI睡眠模式和急性中风的风险:INTERSTROKE国际病例对照研究的结果- 10.1212 / WNL援助。0000000000207249 DP - 2023年4月05 TA -神经病首页学PG - 10.1212 / WNL。0000000000207249 4099 - http://n.首页neurology.org/content/early/2023/04/05/WNL.0000000000207249.short 4100 - //www.ez-admanager.com/content/early/2023/04/05/WNL.0000000000207249.full AB -背景和目的:睡眠障碍是常见的症状,可能代表重要的可改变的中风危险因素。我们评估之间的联系的睡眠障碍症状和急性中风的风险在国际设置。方法:INTERSTROKE是国际第一急性中风患者的病例对照研究和控制相应的年龄(+ / - 5年)和性。睡眠症状前一个月通过问卷进行评估。条件逻辑回归估计睡眠障碍症状和急性中风之间的关系,表示为优势比和95%置信区间。的主要模型调整年龄、职业、婚姻状况和modified-Rankin规模在基线,后续模型调整潜在介质(行为/疾病危险因素)。结果:总体而言,4496年与参与者包括了1799个参与者经历了缺血性中风和439个颅内出血。Short sleep (<5hrs: 3.15, 2.09-4.76), long sleep (>9hr: 2.67, 1.89-3.78), impaired quality (1.52, 1.32-1.75), difficulty getting to sleep (1.32, 1.13-1.55) or maintaining sleep (1.33, 1.15-1.53), unplanned napping (1.59, 1.31-1.92), prolonged napping (>1hr: 1.88, 1.49-2.38), snoring (1.91, 1.62-2.24), snorting (2.64, 2.17-3.20) and breathing cessation (2.87, 2.28-2.60) were all significantly associated with increased odds of acute stroke in the primary model. A derived Obstructive Sleep Apnoea (OSA) score of 2-3 (2.67, 2.25-3.15) and cumulative sleep symptoms (>5: 5.06, 3.67-6.97) were also associated with a significantly increased odds of acute stroke, with the latter showing a graded association. Following extensive adjustment, significance was maintained for the majority of symptoms (not difficulty getting to/maintaining sleep and unplanned napping), with similar findings for stroke subtypes.Discussion: We found that sleep disturbance symptoms were common, and associated with a graded increased risk of stroke. These symptoms may be a marker of increased individual risk, or represent independent risk factors. Future clinical trials are warranted to determine the efficacy of sleep interventions in stroke prevention.