@article {Mc Carthy10.1212 / WNL。0000000000207249,作者= {Christine艾琳Mc凯西和Salim Yusuf康纳法官和阿尔贝托Alvarez-Iglesias格雷姆j .纸巾和Shahram Oveisgharan和Albertino Damasceno和赫勒克林根贝格球队和安妮卡罗森格Alvaro Avezum会长Patricio Lopez-Jaramillo丹尼斯·泽维尔和王Xingyu Sumathy Rangarajan周二和马丁O {\ textquoteright} Donnell}, title ={睡眠模式和急性中风的风险:INTERSTROKE国际病例对照研究的结果},elocation-id = {10.1212 / WNL。={2023}0000000000207249},年,doi = {10.1212 / WNL。出版商0000000000207249}= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={背景和目的:睡眠障碍是常见的症状,并可能代表重要的可改变的中风危险因素。首页我们评估之间的联系的睡眠障碍症状和急性中风的风险在国际设置。方法:INTERSTROKE是国际第一急性中风患者的病例对照研究和控制相应的年龄(+ / - 5年)和性。睡眠症状前一个月通过问卷进行评估。条件逻辑回归估计睡眠障碍症状和急性中风之间的关系,表示为优势比和95 \ %的置信区间。的主要模型调整年龄、职业、婚姻状况和modified-Rankin规模在基线,后续模型调整潜在介质(行为/疾病危险因素)。结果:总体而言,4496年与参与者包括了1799个参与者经历了缺血性中风和439个颅内出血。短睡眠(\ < 5小时:3.15,2.09 - -4.76),长时间睡眠(\ > 9小时:2.67,1.89 - -3.78),受损的质量(1.52,1.32 - -1.75),入睡困难(1.32,1.13 - -1.55)或保持睡眠(1.33,1.15 - -1.53),计划外打盹(1.59,1.31 - -1.92),长时间的小睡(\ > 1小时:1.88,1.49 - -2.38),打鼾(1.91,1.62 - -2.24),吸食(2.64,2.17 - -3.20)和呼吸停止(2.87,2.28 - -2.60)均显著地增加急性中风的几率在主模型。派生的阻塞性睡眠呼吸暂停(OSA)的2 - 3(2.67,2.25 - -3.15)和累积睡眠症状(\ > 5:5.06,3.67 - -6.97)也与急性中风的几率大大增加,后者显示分级协会。 Following extensive adjustment, significance was maintained for the majority of symptoms (not difficulty getting to/maintaining sleep and unplanned napping), with similar findings for stroke subtypes.Discussion: We found that sleep disturbance symptoms were common, and associated with a graded increased risk of stroke. These symptoms may be a marker of increased individual risk, or represent independent risk factors. Future clinical trials are warranted to determine the efficacy of sleep interventions in stroke prevention.}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/early/2023/04/05/WNL.0000000000207249}, eprint = {//www.ez-admanager.com/content/early/2023/04/05/WNL.0000000000207249.full.pdf}, journal = {Neurology} }