@article {Di Luca10.1212 / WNL。0000000000207247,作者={丹尼尔加宾风迪卢卡盛罗和Hongliang刘媚兰科恩和托马斯·l·戴维斯和Adoldo Ramirez-Zamora负责人wafez和米里亚姆拉弗蒂早Dahodwala和安娜Naito玛丽莲Neault和詹姆斯·贝克和康妮马拉},title ={种族和民族的差异对个人健康相关的生活质量与帕金森病在卓越中心},elocation-id = {10.1212 / WNL。={2023}0000000000207247},年,doi = {10.1212 / WNL。出版商0000000000207247}= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={背景和目标:种族和少数民族代表帕金森疾病(PD) {\ textquoteri首页ght}年代研究,限制了我们对治疗和结果的理解在所有非白人群体。本研究的目的是探讨健康相关的生活质量变化(HRQoL),和其他结果PD患者在不同人种和种族。方法:这是一个回顾,横向和纵向队列研究的个人评估在PD的卓越中心。多变量回归分析调整性别、年龄、疾病持续时间、Hoehn和Yahr (H \ y)阶段,并存病和认知评分被用来调查种族和族裔群体之间的差异。开展了多元回归skewed-t错误评估每个变量的个人贡献与种族和民族PDQ-39协会。结果:共有8514名参与者至少一个记录的访问。绝大多数(90.2 \ %)自认为白色(n = 7687),其次是5.81 \ %拉美裔(n = 495), 2 \ %亚洲人(n = 170)、和1.9 \ %的非裔美国人(162)。调整后,总PDQ-39分数更高(更糟糕的)的非洲裔美国人(28.56),西班牙裔(26.62)和亚洲人(25.43)相比,白色的病人(22.73,p < 0.001)。在大多数PDQ-39分量表这种差异也显著。在纵向分析,包含认知得分显著降低PDQ-39协会的力量,种族/民族少数民族。 A mediation analysis demonstrated that cognition partially mediated the association between race/ethnicity and PDQ-39 scores (proportion mediated 0.251, p \<0.001).Discussion: There were differences in PD outcomes across racial and ethnic groups, even after adjustment for sex, disease duration, HY stage, age and some comorbid conditions. Most notably, there was worse HRQoL among non-Whites when compared to White patients, which was partially explained by cognitive scores. The underlying reason for these differences needs to be a focus of future research.}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/early/2023/04/05/WNL.0000000000207247}, eprint = {//www.ez-admanager.com/content/early/2023/04/05/WNL.0000000000207247.full.pdf}, journal = {Neurology} }