RT期刊文章SR电子T1静脉溶栓开始转移前中风血管内血栓切除术摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP e1436 OP e1443 10.1212 / WNL。首页100签证官0000000000206784是14 A1 Aristeidis h . Katsanos A1 Amrou Sarraj A1迈克尔Froehler A1 Jan Purrucker A1 Nitin Goyal A1罗伯特·威廉Regenhardt A1莉娜Palaiodimou A1尼尔斯·h·Mueller-Kronast A1罗宾Lemmens A1彼得·d·谢林A1西蒙娜A1的焦点在于Guillaume Turc A1安德烈诉Alexandrov A1乔治Tsivgoulis年2023 UL //www.ez-admanager.com/content/100/14/e1436.abstract AB背景和目标静脉溶栓的作用(溶)患者大血管遮挡(LV首页Os)管理转移之前从主中风研究中心(PSC)综合中风中心(CSC)质疑。方法包括观察性研究的一个LVO患者接受溶在PSC前血管内血栓切除术(EVT)传输与接收EVT孤单。疗效结果包括优秀或良好的功能结果(改良Rankin规模(夫人)得分0 - 1或0 - 2,分别),减少残疾(夫人转变分析)在3个月。安全结果包括症状性颅内出血(西奇)在48小时内和3个月的全因死亡率。协会报告与原油优势比口服补液盐(ORs)和调整(aor)。我们确定了6个研究结果,其中包括1723名参与者(平均年龄:71年,51%的女性;诊断和治疗PSC) 53%。平均onset-to-groin穿刺时间两组之间没有差别(平均差:−20分钟,95% CI 115.89−76.04)。患者接受溶在转移之前有更高的几率3个月减少残疾(普通或= 1.98,95% CI 1.17 - -3.35),优秀(或= 1.70,95% CI 1.28 - -2.26),和良好的(或= 1.62.95%可信区间1.15 - -2.29)功能的结果,在没有增加西奇(或= 0.87,95% CI 0.54 - -1.39)或死亡率(或= 0.55,95% CI 0.37 - -0.83)的风险。调整分析,在PSC患者早期诊断有更高的几率的功能性结果(优势比= 1.32,95% CI 1.00 - -1.74)和概率较低的死亡率(优势比= 0.50,95% CI 0.27 - -0.93)。Discussion Patients with LVO receiving IVT at a PSC before an EVT transfer have a higher likelihood of excellent functional recovery and lower odds of mortality, with no increase in sICH and onset-to-groin puncture times, compared with those transferred for EVT without previously receiving IVT.aOR=adjusted OR; CSC=comprehensive stroke center; EVT=endovascular thrombectomy; LVO=large vessel occlusion; mRS=modified Rankin Scale; NIHSS=NIH Stroke Scale; OR=odds ratio; PSC=primary stroke center; RCT=randomized controlled clinical trial; ROBINS-I=Risk of Bias in nonrandomized Studies; sICH=symptomatic intracranial hemorrhage