PT -期刊文章盟约翰·韦尔温克曼主持非盟-本杰明wip盟Jordana Zackon TI -长期安全剂量稳定,阿片类药物的功效不宁腿综合症患者在全国RLS - 10.1212 / WNL阿片类药物注册援助。0000000000206855 DP - 2023年4月04 TA -神经病首页学PG - e1520 e1528 VI - 100 IP - 14 4099 - //www.ez-admanager.com/content/100/14/e1520.short 4100 - //www.ez-admanager.com/content/100/14/e1520.full所以Neurology2023 4月04;100 AB -背景和目标不宁腿综合症(RLS)是一种感觉神经障碍。低剂量的阿片类药物是耐火材料或增强RLS患者规定。长期安全、稳定剂量和疗效RLS的这些药物治疗仍不清楚。在这项研究中,我们报告2年期纵向数据样本RLS阿片类药物患者的社区。方法全国RLS阿片类药物注册表是一个观察个人服用处方阿片类药物组成的纵向研究诊断和确认RLS,大多数人经历的症状增强多巴胺受体激动剂。信息阿片类药物剂量,副作用,过去和当前伴随RLS治疗,RLS严重性,精神症状,阿片类药物滥用的风险因素是初始注册表项的收集和调查每6个月之后的搬运工。没有反馈或干预研究人员所提供的本地供应商。结果注册参与者(n = 448), 2年纵向数据大多是白色,女,年龄超过60岁,而且,在注册表项,已经对阿片类药物的平均1 - 3年的意思是吗啡毫克当量(MME) 38.4 (SD = 43.5)。没有改变RLS严重性在整个队列在2年随访期间观察到的。 The median change in daily opioid dose from baseline to 2 years was 0 MME (interquartile range = 0–10). While 41.1% of participants increased their dose during the follow-up period (median increase = 10 MME), 58.9% decreased their dose or saw no change. Only 8% and 4% saw increases of >25 MME and >50 MME, respectively. Ninety-five percent of those who increased opioid dose >25 or >50 MME had one of the following features: switching opioids, discontinuation of nonopioid RLS treatment medications, at least mild insomnia at baseline, a history of depression, male sex, younger than 45 years, and opioid use for comorbid pain.Discussion Low-dose opioid medications continue to adequately control symptoms of refractory RLS over 2 years of follow-up in most of the participants. A minority of patients did see larger dose increases, which were invariably associated with a limited number of factors, most notably changes in opioid and nonopioid RLS medications and opioid use for a non-RLS condition. Continued longitudinal observations will provide insight into the long-term safety and efficacy of opioid treatment of severe, augmented RLS.Classification of Evidence This study provides Class IV evidence that opioid doses increase in roughly 40% of patients, in most by small amounts, over a 2-year period when prescribed for adult refractory restless leg syndrome.GAD-7=generalized anxiety disorder-7 scale; IRLS=International Restless Legs Syndrome Study Group Severity Scale; ISI=insomnia severity index; MDD=major depressive disorder; MME=morphine milligram equivalent; PHQ-9=Patient Health Questionnaire; RLS=restless legs syndrome; RLSF=Restless Legs Syndrome Foundation