% 0期刊文章% Aymeric麦洛% Louis-Marie梗%一个Bertrand Mathon %克利斯朵夫Joubert % Thiebaud Picart %一Luc Bauchet文森特Jecko % % Florian伯纳德% Xavier卡斯特尔%一个路易Chenin % Ann-Rose厨师%伊金刚砂%一Guillaume Gauchotte多米尼克Figarella-Branger % %一个托马斯Graillon %安妮Jouvet %米歇尔Kalamarides %一个Arnaud Lazard史蒂文Knafo % %一个文森特Lubrano % (Karima Mokhtari称% Valerie Rigau %一个奥黛丽卢梭文森特Roualdes % %一个Romuald Seizeur %一个吉米Voirin Emmanuelle Uro-Coste % %一个Philippe Metellus % Johan Pallud % Ilyess Zemmoura %和髓胶质母细胞瘤的研究小组% T的自然病程和预后主要脊髓胶质母细胞瘤% B一项全国性研究% D R 10.1212 / WNL 2023%。0000000000206834 % J首页神经病学% P e1497-e1509 % V 100% N 14% X背景和目标主要脊髓胶质母细胞瘤(PsGBM)是极为罕见。戏剧性的神经恶化和由PsGBM使它特别禁用恶性肿瘤。因为它是一种罕见的和异构疾病,预后因素的评估仍然是有限的。方法确定PsGBMs从法国脑瘤数据库和俱乐部de Neuro-Oncologie法国Neurochirurgie回顾性的法国。入选标准是18岁或以上诊断,脊椎位置,新胶质母细胞瘤的病理诊断根据2016年世界卫生组织分类,和手术管理在2004年和2016年之间。诊断证实了一个集中neuropathologic审查。主要结果是总生存期(OS)。治疗性干预措施和神经的结果也被收集。结果33组织病理学证实PsGBM患者(平均年龄50.9岁)包括(中心27日)。操作系统中值为13.1个月(范围2.5 - -23.7),和中位无进展生存期是5.9个月(范围1.6 - -10.2)。 In multivariable analyses using Cox model, Eastern Cooperative Oncology Group (ECOG) performance status at 0–1 was the only independent predictor of longer OS (hazard ratio [HR] 0.13, 95% CI 0.02–0.801; p = 0.02), whereas a Karnofsky performance status (KPS) score <60 (HR 2.89, 95% CI 1.05–7.92; p = 0.03) and a cervical anatomical location (HR 4.14, 95% CI 1.32–12.98; p = 0.01) were independent predictors of shorter OS. The ambulatory status (Frankel D–E) (HR 0.38, 95% CI 0.07–1.985; p = 0.250) was not an independent prognostic factor, while the concomitant standard radiochemotherapy with temozolomide (Stupp protocol) (HR 0.35, 95% CI 0.118–1.05; p = 0.06) was at the limit of significance.Discussion Preoperative ECOG performance status, KPS score, and the location are independent predictors of OS of PsGBMs in adults. Further analyses are required to capture the survival benefit of concomitant standard radiochemotherapy with temozolomide.CT=chemotherapy; ECOG=Eastern Cooperative Oncology Group; FBTDB=French Brain Tumor Database; FLAIR=fluid-attenuated inversion recovery; FU=follow-up; GBM=glioblastoma; HR=hazard ratio; IDH=isocitrate dehydrogenase; KPS=Karnofsky performance status; MGMT=O(6)-methylguanine-DNA methyltransferase; OS=overall survival; PFS=progression-free survival; PsGBM=primary spinal glioblastoma; RENOCLIP=Réseau de Neuro-Oncologie CLInico Pathologique; RENOP=Réseau de Neuro-oncologie pathologique; RT=radiotherapy; STR=subtotal resection surgery; TERT=telomerase reverse transcriptase; WHO=World Health Organization %U //www.ez-admanager.com/content/neurology/100/14/e1497.full.pdf