@article {van der Meere1488作者= {Pim b·范德梅尔先生和琳达小说和玛塔Fiocco Maaike j·沃斯·马蒂尔德、蔡玫Kouwenhoven和马丁j . van den弯曲和马丁J.B. Taphoorn和约翰自动跟踪Koekkoek}, title ={神经胶质瘤患者的抗癫痫药物三联疗法的有效性与难治性癫痫},体积={100}={14},页面= {e1488——e1496} = {2023}, doi = {10.1212 / WNL。出版商0000000000206852}= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={背景和目标大约10 \ %的神经胶质瘤患者癫痫需要抗癫痫药物(ASM)三联疗法首页由于难治性癫痫。本研究的目的是评估是否levetiracetam结合丙戊酸和clobazam (LEV + VPA + CLB),经常开三联疗法,有良好的效果相比其他三联疗法组合神经胶质瘤患者。这是一个多中心回顾性观察性队列研究的方法。主要结果是时间的累积发生率治疗失败的原因,从一开始的ASM三联疗法治疗。二级结果包括累积发生率如下:(1)由于不受控制的癫痫治疗失败时间;(2)治疗失败时间由于副作用;和(3)反复发作的时间。随访的最大持续时间36个月。结果1435名患者在最初的队列中,90名患者接受ASM三联疗法后二线ASM由于不受控制的癫痫治疗失败。列弗+ VPA + CLB是规定48 \ %(43/90)和其他ASM三联疗法52 \ %(47/90)的患者。治疗失败的任何原因的累积发病率列弗+ VPA + CLB没有统计上显著不同于其他ASM三联疗法组合(12个月:47 \ [95 \ % CI 31 \ % {\ textendash} 62 \ %)和42 \ % CI 27 \ [95 \ % % {\ textendash} 56 \ %], p = 0.892)。 No statistically significant differences for treatment failure due to uncontrolled seizures (12 months: 12\% [95\% CI 4\%{\textendash}25\%] vs 18\% [95\% CI 8\%{\textendash}30\%], p = 0.445), adverse effects (12 months: 22\% [95\% CI 11\%{\textendash}36\%] vs 15\% [95\% CI 7\%{\textendash}27\%], p = 0.446), or recurrent seizures (1 month: 65\% [95\% CI 48\%{\textendash}78\%] vs 63\% [95\% CI 47\%{\textendash}75\%], p = 0.911) were found.Discussion LEV + VPA + CLB might show equivalent effectiveness compared with other ASM triple therapy combinations in patients with glioma.Classification of Evidence This study provides Class III evidence that for patients with glioma with refractory epilepsy on triple therapy ASMs, LEV + VPA + CLB demonstrated similar effectiveness and tolerability compared with other ASM triple therapy combinations.ASM=antiseizure medication; BTRE=brain tumor{\textendash}related epilepsy; CLB=clobazam; DDD=defined daily dosage; GABA=gamma aminobutyric acid; LCM=lacosamide; LEV=levetiracetam; PER=perampanel; VPA=valproic acid; WHO=World Health Organization}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/100/14/e1488}, eprint = {//www.ez-admanager.com/content/100/14/e1488.full.pdf}, journal = {Neurology} }