癫痫患儿颞叶切除后记忆短期预后的表征和预测[j] .神经病学，2010 . 10.1212/WNL.0000000000207143首页Sp - 10.1212/ wnl.0000000000207143AU - Navkiranjot Kaur AU - Amy S. Nowacki AU - Deepak K. Lachhwani AU - Madison M Berl AU - Marla J. Hamberger AU - Patricia Klaas AU - William Bingaman AU - Robyn M Busch Y1 - 2023/03/16 UR - http://n.首页neurology.org/content/early/2023/03/15/WNL.0000000000207143.abstract N2 -目标:(1)通过儿童记忆量表(CMS)评估癫痫患儿颞叶切除后情景记忆的短期结果，使用评估认知变化的经验方法(即可靠的变化指数:rci和基于标准化回归的变化评分:srb);(2)开发并内部验证临床适用的模型，以预测术后记忆衰退。方法:这项回顾性队列研究包括6-16岁的儿童，他们接受了切除癫痫手术，包括颞叶(仅颞叶:“颞叶”和多叶:“颞叶+”)，并完成了包括CMS在内的术前和术后神经心理学评估。使用癫痫特异性rci和srb, CMS延迟记忆子测试(面孔、故事和单词对)的变化得分分为下降、无变化或改善。我们开发了预测术后记忆衰退的逻辑回归模型，并通过自助进行了内部验证。结果:在纳入的126名儿童中，大多数在手术后中位7个月的个体测量中显示RCI没有显著变化(54-69%)或改善(8-14%)。一部分儿童(23-33%)出现术后衰退。rci和srb的变化分布差异无统计学意义。术前记忆测试评分、手术部位、手术范围和术前全量表智商是记忆衰退的预测因子。 Prediction models for memory decline included subsets of these variables with bias-corrected concordance (c) statistics ranging from 0.70-0.75. The models were well calibrated although slightly overestimated the probability of verbal memory decline in high risk patients.Discussion: This study used empiric methodology to characterize memory outcome in children following temporal lobe resection. Provided online calculator and nomograms may be used by clinicians to estimate the risk of postoperative memory decline for individual patients prior to surgery. ER -