@article {Kaur10.1212 / WNL。0000000000207143，作者= {Navkiranjot Kaur and Amy S. Nowacki and Deepak K. Lachhwani and Madison M Berl and Marla J. Hamberger and Patricia Klaas and William Bingaman and Robyn M Busch}，标题={癫痫患儿颞叶切除术后记忆短期结果的表征和预测}，位置-id = {10.1212/WNL。0000000000207143}，年份= {2023}，doi = {10.1212/WNL。0000000000207143}，出版商= {Wolters Kluwer Health, Inc.代表美国神经病学学会}，摘要={目的:(1)表征儿童记忆量表(CMS)评估的癫痫患儿颞叶切除首页后情景记忆的短期结果，使用经验方法评估认知变化(即可靠的变化指数:rci和基于标准化回归的变化评分);(2)开发并内部验证临床适用的模型来预测术后记忆衰退。方法:本回顾性队列研究纳入6-16岁接受切除性癫痫手术的儿童，包括颞叶(仅颞叶:{\textquotedblleft}颞叶{\textquotedblright}和多叶:{\textquotedblleft}颞叶+ {\textquotedblright})，并完成了包括CMS在内的术前和术后神经心理学评估。使用癫痫特异性rci和srb, CMS延迟记忆子测试(面孔、故事和单词对)的变化得分分为下降、无变化或改善。我们开发了预测术后记忆衰退的逻辑回归模型，并通过自助进行了内部验证。结果:在纳入的126名儿童中，大多数在手术后中位7个月的个体测量中显示RCI没有显著变化(54- 69%)或改善(8- 14%)。一部分儿童(23- 33%)出现术后衰退。rci和srb的变化分布差异无统计学意义。 Preoperative memory test score, surgery side, surgery extent, and preoperative full scale IQ were predictors of memory decline. Prediction models for memory decline included subsets of these variables with bias-corrected concordance (c) statistics ranging from 0.70-0.75. The models were well calibrated although slightly overestimated the probability of verbal memory decline in high risk patients.Discussion: This study used empiric methodology to characterize memory outcome in children following temporal lobe resection. Provided online calculator and nomograms may be used by clinicians to estimate the risk of postoperative memory decline for individual patients prior to surgery.}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/early/2023/03/15/WNL.0000000000207143}, eprint = {//www.ez-admanager.com/content/early/2023/03/15/WNL.0000000000207143.full.pdf}, journal = {Neurology} }