@article {Fisch10.1212 / WNL。0000000000207129,作者= {Fisch, Urs和J{\"u}nger, Anja L.和Baumann, Sira M和Semmlack, Saskia和De Marchis, Gian Marco和Hunziker, Sabina和R{\"u}eggFAES, Stephan和Marsch, Stephan和Sutter, Raoul},标题={诱导爆发抑制与难治性癫痫持续状态患者的临床结果之间的关系:9年队列研究},定位-id = {10.1212/WNL。0000000000207129}, year = {2023}, doi = {10.1212/WNL。0000000000207129},出版商= {Wolters Kluwer Health, Inc.代表美国神经病学学会},摘要={目的:探讨持续性静脉麻醉(IVAD)中诱导脑电图(EEG)爆首页发抑制模式的频率和治疗难耐性癫痫持续状态(RSE)的成人患者的相关结局。方法:纳入2011-2019年在瑞士学术护理中心接受麻醉药治疗的RSE患者。评估临床资料和半定量脑电图分析。抑爆分为不完全抑爆(>=20\%,抑爆比例\<50\%)和完全抑爆(>=50\%)。诱发发作抑制的频率以及发作抑制与结局(持续发作终止、住院生存率和恢复发病前神经功能)的相关性为终点。结果:我们确定了147例接受IVAD治疗的RSE患者。在102例无脑缺氧患者中,14例(14%)实现了不完全爆发抑制,中位数为23小时(四分位范围[IQR] 1-29), 21例(21%)实现了完全爆发抑制,中位数为51小时(IQR 16-104)。年龄、Charlson共病指数、伴有运动症状的RSE和癫痫持续状态严重程度评分(stress)被认为是在有和没有任何爆发抑制的患者之间进行单变量比较的潜在混杂因素。多变量分析显示任何抑制爆发与预定义终点之间没有关联。然而,在45例脑缺氧患者中,诱发性爆发抑制与持续性癫痫发作终止(72 %无爆发抑制vs. 29 %有爆发抑制,p=0.004)和生存率(50\% vs. 14\% p=0.005)相关。Conclusions: In adult patients with RSE treated with IVAD, burst-suppression with >=50\% suppression proportion was achieved in every fifth patient and not associated with persistent seizure termination, in-hospital survival or return to premorbid neurologic function.}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/early/2023/03/08/WNL.0000000000207129}, eprint = {//www.ez-admanager.com/content/early/2023/03/08/WNL.0000000000207129.full.pdf}, journal = {Neurology} }
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