TY - JOUR T1 -老年癫痫患者虚弱与抗癫痫药物耐受性之间的关系JF -神经学JO -神经学SP - e1135 LP - e1147 DO - 10.1212/WNL.0000000000201701首页VL - 100 IS - 11 AU - Arielle Vary-O'Neal AU - Sareh Miranzadeh AU - Nafisa Husein AU - Jayna Holroyd-Leduc AU - Tolulope T. Sajobi AU - Samuel Wiebe AU - Charles Deacon AU - Jose Francisco Tellez-Zenteno AU - Colin Bruce Josephson AU - Mark R. Keezer Y1 - 2023/03/14 UR - http://n.首页neurology.org/content/100/11/e1135.abstract N2 -背景和目标脆弱是生物衰老的一个重要方面，指的是个体对生理和心理压力的脆弱性增加。虽然老年癫痫患者是一个重要而独特的临床群体，但在这一人群中没有关于衰弱的数据。我们假设衰弱与癫痫发作频率相关，特别是与老年癫痫患者抗癫痫药物(asm)的耐受性相关。方法:我们从4个加拿大医院中心招募了60岁或以上的活动性癫痫患者。我们报告了访谈前3个月的癫痫发作频率，同时使用利物浦不良事件档案(LAEP)量化ASM耐受性。我们采用了3种虚弱的测量方法:握力作为身体虚弱的测量方法，1种自我报告评分(埃德蒙顿虚弱评分[EFS])， 1种由医疗保健专业人员完成的量表(临床虚弱量表[CFS])。我们还进行了标准化问卷调查，测量焦虑、抑郁、功能残疾和生活质量的水平，并获得了相关的临床和人口统计学数据。研究招募了43名女性和43名男性，年龄在60-93岁之间，其中87%患有局灶性癫痫，平均每月发作3.4次。多元线性回归和零膨胀负二项回归模型显示，EFS和CFS评分与ASM耐受性降低相关，LAEP评分每增加1分，分别增加1.83 (95% CI: 0.67-4.30)和2.49 (95% CI: 1.27-2.39)点。EFS和CFS评分以及握力与癫痫发作频率均无显著相关性。 The EFS was moderately correlated with depression, anxiety, quality of life, and functional disability, demonstrating the best construct validity among the 3 tested measures of frailty.Discussion The EFS was significantly, both statistically and clinically, associated with ASM tolerability. It also showed multiple advantages in performance while assessing for frailty in older adults with epilepsy, when compared with the 2 other measures of frailty that we tested. Future studies must focus on what role the EFS during epilepsy diagnosis may play in ASM selection among older adults with epilepsy.ASMs=antiseizure medications; ADL=activities of daily living; CFS=clinical frailty scale; EFS=Edmonton frail score; ESI=epilepsy-specific comorbidity index; GAD-7=generalized anxiety disorder 7-item scale; LAEP=Liverpool Adverse Events Profile; MD=mean difference; NDDI-E=neurologic disorders depression inventory for epilepsy; QOLIE-10=quality of life in epilepsy 10-item scale; ZINBR=zero-inflated negative binomial regression ER -