TY - JOUR T1 -晚期脑年龄和慢性卒中后失语严重程度JF -神经学JO -神经学SP - e1166 LP - e1176 DO - 10.1212首页/WNL.0000000000201693六世- 100 - 11盟——娜塔莉·巴斯比非盟——怪不得我Wilmskoetter Ezequiel Gleichgerrcht盟盟- -克里斯Rorden盟丽贝卡·罗斯AU -罗杰Newman-Norlund盟Argye伊丽莎白Hillis AU -西蒙·s·凯勒AU - Christophe de Bezenac盟Sigfus Kristinsson AU -朱利叶斯Fridriksson盟莱昂纳多Bonilha Y1 - 2023/03/14 UR - //www.ez-admanager.com/content/100/11/e1166.abstract N2 -背景和目标慢性卒中后语言障碍通常是在老年人和那些有大量更糟糕首页stroke lesions. However, there is unexplained variance that likely depends on intact tissue beyond the lesion. Brain age is an emerging concept, which is partially independent from chronologic age. Advanced brain age is associated with cognitive decline in healthy older adults; therefore, we aimed to investigate the relationship with stroke aphasia. We hypothesized that advanced brain age is a significant factor associated with chronic poststroke language impairments, above and beyond chronologic age, and lesion characteristics.Methods This cohort study retrospectively evaluated participants from the Predicting Outcomes of Language Rehabilitation in Aphasia clinical trial (NCT03416738), recruited through local advertisement in South Carolina (US). Primary inclusion criteria were left hemisphere stroke and chronic aphasia (≥12 months after stroke). Participants completed baseline behavioral testing including the Western Aphasia Battery–Revised (WAB-R), Philadelphia Naming Test (PNT), Pyramids and Palm Trees Test (PPTT), and Wechsler Adult Intelligence Scale Matrices subtest, before completing 6 weeks of language therapy. The PNT was repeated 1 month after therapy. We leveraged modern neuroimaging techniques to estimate brain age and computed a proportional difference between chronologic age and estimated brain age. Multiple linear regression models were used to evaluate the relationship between proportional brain age difference (PBAD) and behavior.Results Participants (N = 93, 58 males and 35 females, average age = 61 years) had estimated brain ages ranging from 14 years younger to 23 years older than chronologic age. Advanced brain age predicted performance on semantic tasks (PPTT) and language tasks (WAB-R). For participants with advanced brain aging (n = 47), treatment gains (improvement on the PNT) were independently predicted by PBAD (T = −2.0474, p = 0.0468, 9% of variance explained).Discussion Through the application of modern neuroimaging techniques, advanced brain aging was associated with aphasia severity and performance on semantic tasks. Notably, therapy outcome scores were also associated with PBAD, albeit only among participants with advanced brain aging. These findings corroborate the importance of brain age as a determinant of poststroke recovery and underscore the importance of personalized health factors in determining recovery trajectories, which should be considered during the planning or implementation of therapeutic interventions.TE=echo time; TI=inversion time; PBAD=proportional brain age difference; PNT=Philadelphia Naming Test; PPTT=Pyramids and Palm Trees Test; POLAR=Predicting Outcomes of Language Rehabilitation in Aphasia; TR=repetition time; WAB-AQ=Western Aphasia Battery–Aphasia Quotient; WAB-R=Western Aphasia Battery–Revised; WAIS=Wechsler Adult Intelligence Scale ER -