% 0期刊文章% Andres m . Kanner % Anita董s Saporta % h . Kim %约翰·j·巴里%岩漠Altalib %希望Omotola %娜塔莉Jette %特伦斯j . O ' brien %悉达多纳卡尼%一个旋律r . Winawer %迈克尔·斯珀林%杰奎琳·A . Brian Alldredge法国%巴塞尔因车祸Abou-Khalil % %一个格里高利·d·Cascino马蒂娜Bebin % %安德鲁·j·科尔% Mark j .厨师%一个奥林卡米尔Detyniecki % Devinsky %一个爱德华Faught丹尼斯Dlugos % %一个大卫·菲克% %一个巴里Gidal %迈克尔·玛德琳字段Gelfand %A Simon Glynn %A Jonathan J. Halford %A Sheryl Haut %A Manu Hegde %A Manisha G. Holmes %A Reetta Kalviainen %A Joon Kang %A Pavel Klein %A Robert C. Knowlton %A Kaarkuzhali Krishnamurthy %A Ruben Kuzniecky %A Patrick Kwan %A Daniel H. Lowenstein %A Lara Marcuse %A Kimford J. Meador %A Scott Mintzer %A Heath R. Pardoe %A Kristen Park %A Patricia Penovich %A Rani K. Singh %A Ernest Somerville %A Charles A. Szabo %A Jerzy P. Szaflarski %A K. Liu Lin Thio %A Eugen Trinka %A Jorge G. Burneo %A and the Human Epilepsy Project %T Mood and Anxiety Disorders and Suicidality in Patients With Newly Diagnosed Focal Epilepsy %B An Analysis of a Complex Comorbidity %D 2023 %R 10.1212/WNL.0000000000201671 %J Neurology %P e1123-e1134 %V 100 %N 11 %X Background and Objectives Mood, anxiety disorders, and suicidality are more frequent in people with epilepsy than in the general population. Yet, their prevalence and the types of mood and anxiety disorders associated with suicidality at the time of the epilepsy diagnosis are not established. We sought to answer these questions in patients with newly diagnosed focal epilepsy and to assess their association with suicidal ideation and attempts.Methods The data were derived from the Human Epilepsy Project study. A total of 347 consecutive adults aged 18–60 years with newly diagnosed focal epilepsy were enrolled within 4 months of starting treatment. The types of mood and anxiety disorders were identified with the Mini International Neuropsychiatric Interview, whereas suicidal ideation (lifetime, current, active, and passive) and suicidal attempts (lifetime and current) were established with the Columbia Suicidality Severity Rating Scale (CSSRS). Statistical analyses included the t test, χ2 statistics, and logistic regression analyses.Results A total of 151 (43.5%) patients had a psychiatric diagnosis; 134 (38.6%) met the criteria for a mood and/or anxiety disorder, and 75 (21.6%) reported suicidal ideation with or without attempts. Mood (23.6%) and anxiety (27.4%) disorders had comparable prevalence rates, whereas both disorders occurred together in 43 patients (12.4%). Major depressive disorders (MDDs) had a slightly higher prevalence than bipolar disorders (BPDs) (9.5% vs 6.9%, respectively). Explanatory variables of suicidality included MDD, BPD, panic disorders, and agoraphobia, with BPD and panic disorders being the strongest variables, particularly for active suicidal ideation and suicidal attempts.Discussion In patients with newly diagnosed focal epilepsy, the prevalence of mood, anxiety disorders, and suicidality is higher than in the general population and comparable to those of patients with established epilepsy. Their recognition at the time of the initial epilepsy evaluation is of the essence.ASM=antiseizure medication; BPD=bipolar disorder; CSSRS=Columbia Suicidality Severity Rating Scale; MDD=major depressive disorder; MDE=major depressive episode; MINI=the Mini International Neuropsychiatric Interview; SA=suicidal attempt; SI=suicidal ideation; PWE=people with epilepsy %U //www.ez-admanager.com/content/neurology/100/11/e1123.full.pdf