RT期刊文章SR电子T1的意义脑脊液中髓少突细胞糖蛋白抗体摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP e1095 OP e1108 10.1212 / WNL。首页100签证官0000000000201662 11 A1莎拉的法令A1 Alvaro Cobo卡尔沃A1泰国Armangue A1艾伯特Saiz A1基督教莱希A1凯文Rostasy A1马库斯Breu A1马提亚鲍曼A1和平Hoftberger A1 Ilya Ayzenberg A1卡罗琳Schwake A1玛丽亚赛普维达A1 Eugenia马丁斯A1吉玛Olive-Cirera A1乔治娜Arrambide A1 Mar Tintore A1拉斐尔Bernard-Valnet A1 Renaud Du Pasquier A1 Fabienne Brilot A1 Sudarshini拉马纳坦A1凯瑟琳Schanda A1 Alberto Gajofatto A1塞尔吉奥·法拉利A1伊利亚Sechi A1 Eoin p·弗拉纳根A1肖恩·j·Pittock A1 Vyanka Redenbaugh A1马库斯Reindl A1罗曼Marignier A1莎拉Mariotto年2023 UL //www.ez-admanager.com/content/100/11/e1095.abstract AB背景和目标虽然髓少突细胞糖蛋白antibody-associated疾病的诊断(MOGAD)是基于血清MOG抗体(MOG-Abs)积极性,患者共存或限制MOG-Abs CSF已报告。首页本研究的目的是描述的相关性CSF MOG-Abs积极性在临床实践中。方法11医疗中心回顾性收集临床和实验室数据的成人和儿科患者疑似炎性中枢神经系统疾病和MOG-Abs积极性在血清和CSF使用活细胞分析。使用参数或非参数测试,进行了比较合适的。潜在的不利因素结果探讨Cox比例风险模型和逻辑回归。结果中包括255例:139(55%)妇女和132名儿童(52%)(即。,< 18岁)。其中,145名患者(56.8%)在血清和CSF MOG-Abs (MOG-Abs血清反应阳性的和CSF积极),79(31%)只在血清(MOG-Abs血清反应阳性的和CSF -), 31(12%)只在CSF (MOG-Abs血清和CSF积极)。MOG-Abs血清和CSF积极主导的成年人(22% vs 3%的儿童),送给更常见的运动(n = 14人,45%)和感觉症状(n = 13, 42%),但4(2多发性硬化,1 polyradiculoneuritis, 1 Susac综合征)有一个最终的诊断与MOGAD兼容。当比较血清反应阳性的患者根据MOG-Abs CSF地位,MOG-Abs血清反应阳性的患者CSF积极有较高扩大残疾状态量表(eds)在该指数最低点事件(平均4.5,四分位范围(差)3.0 -7.5 vs 3.0,差2.0 - -6.8,p = 0.007),与感官更常见(45.5%比24%,p = 0.002),电动机(33.6%比19%,p = 0.021),和括约肌症状(26.9%比7.8%,p = 0.001)比MOG-Abs血清反应阳性的和CSF -。在最后随访,MOG-Abs血清反应阳性的和CSF阳性病例往往持续括约肌功能障碍(17.3%比4.3%,p = 0.008)。 Compared with seropositive patients, those MOG-Abs seronegative and CSF positive had higher disability at the last follow-up (p ≤ 0.001), and MOG-Abs seronegative and CSF positive status were independently associated with an EDSS ≥3.0.Discussion Paired serum and CSF MOG-Abs positivity are common in MOGAD and are associated with a more severe clinical presentation. CSF-only MOG-Abs positivity can occur in patients with a phenotype suggestive of MOGAD and is associated with a worse outcome. Taken together, these data suggest a clinical interest in assessing CSF MOG-Abs in patients with a phenotype suggestive of MOGAD, regardless of the MOG-Abs serostatus.Abs=antibodies; ADEM=acute disseminated encephalomyelitis; ARR=annualized relapse rate; CBA=cell-based assays; CNS=central nervous system; CI=confidence interval; DMD=disease-modifying drug; EDSS=Expanded Disability Status Scale; IF=immunofluorescence; IQR=interquartile range; MOG=myelin oligodendrocyte glycoprotein; MOG-Abs=MOG antibodies; MOGAD=myelin oligodendrocyte glycoprotein antibody associated disease; MS=multiple sclerosis; NMOSD=neuromyelitis optica spectrum disorder; OR=odds ratio

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