TY -的T1 - CSF炎症标记物之间的联系,白质病变,个人无痴呆和认知下降JF -神经学乔-神经- 10.1212 / WNL。首页0000000000207113 SP - 10.1212 / WNL。0000000000207113 AU - Eske克里斯蒂Gertje盟Shorena Janelidze AU -丹尼尔·西数盟-尼古拉斯·卡伦AU - Erik Stomrud AU -塞巴斯蒂安Palmqvist盟-奥斯卡·汉森盟Niklas Mattsson-Carlgren Y1 - 2023/03/07 UR - //www.ez-admanager.com/content/early/2023/03/07/WNL.0000000000207113.ab首页stract N2 -背景和ObjectivesSmall血管疾病(计算)和神经炎症都发生在阿尔茨海默病(AD),和其他神经退行性疾病。尚不清楚这些流程是否在广告相关的或独立的机制,特别是在疾病的早期阶段。因此,我们调查了白质病变之间的关系(WML;最常见的表现计算),脑脊液生物标志物的存在及其对认知的影响在人群中没有痴呆。从瑞典BioFINDER MethodsIndividuals无痴呆研究包括在内。CSF分析对促炎的标记(白介素(IL) 6,引发),细胞因子(IL-7, IL-15 IL-16)趋化因子(interferon-γ-induced蛋白10 [IP-10],单核细胞化学引诱物蛋白1,血管损伤的标志(可溶性细胞间粘附分子1、可溶性血管粘附分子1),和血管生成的标记(胎盘生长因子(PlGF),可溶性fms-related酪氨酸激酶1 (sFlt-1),血管内皮生长因子[VEGF-A, VEFG-D]),和Aβ42 Aβ40 P-tau 217。WML量测定在基线和纵向六年。认知测量基线和随访超过8年。线性回归模型被用来测试关联。Results495认知没有(铜)老年人和247例轻度认知障碍(MCI)患者包括在内。 There was significant worsening in cognition over time, measured by MMSE, CDR and mPACC in CU and MCI, with more rapid worsening in MCI for all cognitive tests. At baseline, higher levels of PlGF (β=0.156, p<0.001), lower levels of sFlt-1 (β=-0.086, p=0.003), and higher levels of IL-8 (β=0.07, p=0.030) were associated with more WML in CU. In MCI, higher levels of PlGF (β=0.172, p=0.001), IL-16 (β=0.125, p=0.001), IL-8 (β=0.096, p=0.013), IL-6 (β=0.088, p=0.023), VEGF-A (β=0.068, p=0.028), and VEGF-D (β=0.082, p=0.028) were associated with more WML. PlGF was the only biomarker that was associated with WML independent of Aβ status and cognitive impairment. Longitudinal analyses of cognition showed independent effects of CSF inflammatory markers and WML on longitudinal cognition, especially in people without cognitive impairment at baseline.DiscussionMost neuroinflammatory CSF biomarkers were associated with WML in individuals without dementia. Our findings especially highlight a role for PlGF, which was associated with WML independent of Aβ status and cognitive impairment. ER -