TY - JOUR T1 -无痴呆个体中炎症、白质病变和认知能力下降的CSF标志物之间的关系JF - Neurology JO - Neurology DO - 10.1212/WNL.0000000000207113首页Sp - 10.1212/ wnl.0000000000207113AU - Eske Christiane Gertje AU - Shorena Janelidze AU - Danielle van Westen AU - Nicholas Cullen AU - Erik Stomrud AU - Sebastian Palmqvist AU - Oskar Hansson AU - Niklas Mattsson-Carlgren Y1 - 2023/03/07 UR - http://n.首页neurology.org/content/early/2023/03/07/WNL.0000000000207113.abstract N2 -背景和目的小血管疾病(SVD)和神经炎症都发生在阿尔茨海默病(AD)和其他神经退行性疾病中。目前尚不清楚这些过程在AD中是相关的还是独立的机制，特别是在疾病的早期阶段。因此，我们调查了白质病变(WML;SVD最常见的表现)，以及神经炎症的CSF生物标志物及其对无痴呆症人群认知的影响。方法纳入瑞典BioFINDER研究中无痴呆的个体。分析CSF促炎标志物(白细胞介素[IL] -6, IL-8)，细胞因子(IL-7, IL-15, IL-16)，趋化因子(干扰素-γ诱导蛋白10 [IP-10]，单核细胞趋化蛋白1，血管损伤标志物(可溶性细胞间粘附分子1，可溶性血管粘附分子1)，血管生成标志物(胎盘生长因子[PlGF]，可溶性fms相关酪氨酸激酶1 [sFlt-1]，血管内皮生长因子[VEGF-A，和VEFG-D])和Aβ42。Aβ40和P-tau 217。测定基线和6年以上的纵向WML体积。在基线和8年的随访中测量认知能力。 Linear regression models were used to test associations.Results495 cognitively unimpaired (CU) elderly and 247 patients with mild cognitive impairment (MCI) were included. There was significant worsening in cognition over time, measured by MMSE, CDR and mPACC in CU and MCI, with more rapid worsening in MCI for all cognitive tests. At baseline, higher levels of PlGF (β=0.156, p<0.001), lower levels of sFlt-1 (β=-0.086, p=0.003), and higher levels of IL-8 (β=0.07, p=0.030) were associated with more WML in CU. In MCI, higher levels of PlGF (β=0.172, p=0.001), IL-16 (β=0.125, p=0.001), IL-8 (β=0.096, p=0.013), IL-6 (β=0.088, p=0.023), VEGF-A (β=0.068, p=0.028), and VEGF-D (β=0.082, p=0.028) were associated with more WML. PlGF was the only biomarker that was associated with WML independent of Aβ status and cognitive impairment. Longitudinal analyses of cognition showed independent effects of CSF inflammatory markers and WML on longitudinal cognition, especially in people without cognitive impairment at baseline.DiscussionMost neuroinflammatory CSF biomarkers were associated with WML in individuals without dementia. Our findings especially highlight a role for PlGF, which was associated with WML independent of Aβ status and cognitive impairment. ER -