@article {Yogendrakumar10.1212 / WNL。0000000000207138,作者= {Vignan Yogendrakumar和列昂尼德•Churilov彼得·J·米切尔和蒂莫西·J Kleinig Nawaf Yassi文森特Thijs和泰迪吴沾光沙和彼得·贝利和海伦M杜威和菲利普·马MC崔和爱丽丝和Tissa韦杰和卡洛斯Garcia-Esperon和杰弗里·云Ronil诉钱德拉和丹尼斯·约翰Cordato伯纳德燕DMedSc Gagan Sharma谈话和帕特里夏·米德斯蒙德马克W帕森斯和杰弗里·艾伦唐南和斯蒂芬·M·戴维斯和布鲁斯·c·v·坎贝尔},title = {Tenecteplase安全性和有效性和溶栓串联病变患者中风:EXTEND-IA秋明石油公司的因果分析试验},elocation-id = {10.1212 / WNL。={2023}0000000000207138},年,doi = {10.1212 / WNL。出版商0000000000207138}= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={背景和目的:的安全性和有效性tenecteplase串联病变患者中风是未知的。首页我们进行了比较分析tenecteplase和串联病变患者溶栓。方法:我们首先比较tenecteplase的治疗效果和患者的溶栓串联使用个别患者病变EXTEND-IA秋明石油公司的数据试验。我们在初始评估颅内再灌注血管造影评估和90天的夫人序数物流和弗斯回归模型。因为两个关键结果,死亡率和症状性颅内出血,很少在收到那些溶栓EXTEND-IA秋明石油公司试验,我们生成的混合估计这些结果通过补充试验数据估计入射通过荟萃分析研究确定在系统回顾。然后计算未经调整的风险差异比较集中发病率估计对于那些接受溶栓试验中观察到的那些接收tenecteplase。结果:483年七十一例(15 \ %)EXTEND-IA秋明石油公司试验具有串联病变。病变患者,观察颅内再灌注在11/56 tenecteplase治疗患者(20 \ %)与1/15(7 \ %)溶栓治疗患者(优势比:2.19;95 \ %置信区间:0.28—-17.29)。 No significant difference in 90-day mRS was observed (adjusted common OR: 1.48; 95\% CI: 0.44-5.00). A pooled study-level proportion of alteplase associated mortality and symptomatic intracranial hemorrhage was 0.14 (95\% CI: 0.08-0.21) and 0.09 (95\% CI: 0.04-0.16), respectively. Compared to a mortality rate of 0.09 (95\% CI: 0.03-0.20) and a symptomatic intracranial hemorrhage rate of 0.07 (95\% CI: 0.02-0.17) in tenecteplase treated patients, no significant difference was observed.Conclusions: Functional outcomes, mortality, and symptomatic intracranial hemorrhage did not significantly differ between tenecteplase and alteplase treated tandem lesion patients.Classification of Evidence: This study provides Class III evidence that tenecteplase is associated with similar rates of intracranial reperfusion, functional outcome, mortality, and symptomatic intracranial hemorrhage compared with alteplase, in patients with acute stroke due to tandem lesions. However, the confidence intervals do not rule out clinically important differences.}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/early/2023/03/06/WNL.0000000000207138}, eprint = {//www.ez-admanager.com/content/early/2023/03/06/WNL.0000000000207138.full.pdf}, journal = {Neurology} }