PT -期刊文章盟米歇尔·m·Mielke盟Ryan D弗兰克AU -卢克R克里盟盟朱莉一个字段-沃尔特·A·罗卡盟维斯纳D Garovic TI -妊娠高血压疾病协会与认知- 10.1212 / WNL晚年援助。0000000000207134 DP - 2023年3月01 TA -神经病首页学PG - 10.1212 / WNL。0000000000207134 4099 - http://n.首页neurology.org/content/early/2023/03/01/WNL.0000000000207134.short 4100 - //www.ez-admanager.com/content/early/2023/03/01/WNL.0000000000207134.full AB -背景和目标研究妊娠高血压疾病(黄芪丹参滴丸),包括妊娠期或慢性高血压(GH / CH)和子痫前期/子痫(PE / E),建议对幼年时期和中年认知有限但一直自我报告或使用的诊断代码,排除未生育过的女性,并在晚年缺乏认知的测量。我们检查的影响任何黄芪丹参滴丸,GH / CH, PE / E,未产妇在晚年认知。方法参与者包括2239名妇女(平均年龄73)参加的梅奥诊所研究衰老与医疗记录怀孕抽象信息。认知电池九每15个月进行了测试。全球认知和特定领域的z得分(内存,执行/注意力、视觉空间的语言)的结果。线性混合效应模型评估怀孕之间的联系历史(血压正常的人,任何HPD, HPD亚型(GH / CH、PE / E),或未生育过的)和调整了年龄和教育的认知能力下降。额外的模型调整的APOE、吸烟、高血压、血脂异常、体重指数(BMI)、糖尿病、中风和心脏病。怀孕之间的交互历史和年龄或教育认知性能检查。结果的2239名妇女中,1854(82.8%)至少有一个怀孕(1607年所有的血压正常的人,100年GH / CH 147 PE / E); 385 (17.2%) were nulliparous. Cognitive performance did not cross-sectionally differ for women with a history of any HDP, GH/CH, or PE/E versus women with a history of all normotensive pregnancies; women who were nulliparous had lower global and domain-specific cognition (all p<0.05) in age- and education-adjusted models. There was an interaction (p=0.015) between nulliparity and education such that the lower cognitive performance was most pronounced among nulliparous women with ≤12 years of education (beta = -0.42, p<0.001) versus 12+ years (b = -0.11, p=0.049). Longitudinally, women with any HDP had greater declines in global cognition and attention/executive z-scores compared to women with all normotensive pregnancies. When stratified by HDP type, only women with PE/E had greater declines in global cognition (beta = -0.04, p<0.001), language (beta = -0.03, p=0.001), and attention (beta = -0.04, p<0.001) z-scores. Adjustment for vascular risk factors, BMI, smoking, and APOE did not attenuate results.Discussion Women with a history of HDP, especially PE/E, are at greater risk of cognitive decline in later life.