PT -期刊文章盟央行尼尔斯·延森AU -哈尔德,斯坦蒙克AU -詹森,米氏Micheelsen AU - Bojsen,乔纳斯Asgaard盟——Elhakim穆罕默德塔拉尔盟——Florisson桑德拉AU -萨利赫,艾丽莎AU -克劳森,安妮AU -穆勒,Soren盟——Harbo弗雷德里克雪华铃格盟——Graumann Ole AU -哈拉,Jesper AU -加西亚·罗德里格斯,Luis Alberto盟——Al-Shahi萨尔曼·鲁斯塔姆AU -戈尔茨坦,拉里•b . AU - Gaist大卫TI -联系他汀类药物使用和援助- 10.1212 / WNL脑出血位置。0000000000201664 DP - 2023年3月7日TA -神经病学首页PG e1048——//www.ez-admanager.com/content/100/10/e1048.short e1061 VI - 100 IP - 10 4099 - 4100——//www.ez-admanager.com/content/100/10/e1048.full——Neurology2023 3月7日;100 AB -背景和目标之间的因果关系他汀类药物使用和脑出血(我)是不确定的。我们假设一个长期服用他汀类药物暴露和我风险之间的联系可能因我的位置不同而异。方法:我们使用与丹麦全国注册中心进行了分析。在丹麦南部地区(人口120万),我们确定了我在2009年和2018年之间的所有第一次例≥55岁的人中。医疗record-verified诊断患者分为大叶性或nonlobar我和匹配在年龄、性别和历年普通人群控制。我们使用一个全国性的处方之前注册表来确定他汀类药物和其他药物的使用,我们为近因分类,持续时间和强度。使用条件逻辑回归为潜在的混杂因素调整后,我们计算调整口服补液盐(aor)和相应的95%独联体为大叶性和nonlobar我的风险。结果发现989例肺叶的我(52.2%的女性,平均年龄76.3岁)我们匹配39500控制和1175患者nonlobar我(46.5%的女性,平均年龄75.1岁)我们匹配46755控制。他汀类药物目前风险较低的大叶性(优势比0.83;95%置信区间,0.70 - -0.98)和nonlobar我(优势比0.84; 95% CI, 0.72–0.98). Longer duration of statin use was also associated with a lower risk of lobar (<1 year: aOR 0.89; 95% CI, 0.69–1.14; ≥1 year to <5 years aOR 0.89; 95% CI 0.73–1.09; ≥5 years aOR 0.67; 95% CI, 0.51–0.87; p for trend 0.040) and nonlobar ICH (<1 year: aOR 1.00; 95% CI, 0.80–1.25; ≥1 year to <5 years aOR 0.88; 95% CI 0.73–1.06; ≥5 years aOR 0.62; 95% CI, 0.48–0.80; p for trend <0.001). Estimates stratified by statin intensity were similar to the main estimates for low-medium intensity therapy (lobar aOR 0.82; nonlobar aOR 0.84); the association with high-intensity therapy was neutral.Discussion We found that statin use was associated with a lower risk of ICH, particularly with longer treatment duration. This association did not vary by hematoma location.aOR=adjusted OR; CAA=cerebral amyloid angiopathy; ICH=intracerebral hemorrhage; IVH=intraventricular hemorrhage; RSD=Region of Southern Denmark; SVD=small vessel disease

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