% 0期刊文章% Ademi, Zanfina % Marquina,克拉拉% Perucca,皮耶罗%希区柯克,艾莉森%格雷厄姆,珍妮特%收购,英国央行行长默文•刘j . %,丹尼% O ' brien,特伦斯j . % Vajda,弗兰克·j . % T社区的经济评价的好处澳大利亚怀孕登记的抗癫痫药物% D R 10.1212 / WNL 2023%。0000000000201655 % J首页神经病学% P e1028-e1037 % V 100% N 10% X背景和客观瓦伦堡澳大利亚怀孕登记(APR)建立了收集、分析和发布数据风险的婴儿暴露于抗癫痫药物(asm)和促进质量改进管理保健。它是asm的几个前瞻性观察妊娠登记在世界各地建立了。虽然4月和其他注册中心获得了知识,应用于降低不良妊娠结局,其成本效益仍然是未知的。在这里,我们旨在评估4月从社会和经济影响的卫生保健系统的观点。方法利用决策分析建模,我们估计效果(预防不良妊娠结果)和成本(成本的不良妊娠结局和寄存器本身)的4月在20年的时间范围内(2000 - 2019)。比较器被设置为4月的不良妊娠结果收集在1998年和2002年之间(即。4月,没有得到改善护理)。在情景分析,我们保守假设储蓄的年利率2.5%和5%的贡献在卫生保健和社会成本。不良妊娠结局包括死胎,出生缺陷和人工流产。成本数据都来源于出版来源。 Health and economic outcomes were extrapolated to the total target Australian epilepsy population. The primary outcomes of interest were the return of investment (ROI) for the APR and incremental cost-effectiveness ratio (ICER) for cost per adverse outcome avoided.Results Over the 20-year time horizon, the ROI from the APR from a societal perspective was Australian dollars (AUD) 2,250 (i.e., every dollar spent on the program resulted in a return of AUD2,250). Over this time, it was estimated that 9,609 adverse pregnancy outcomes were avoided, and health care and societal costs were reduced by AUD 191 million and AUD 9.0 billion, respectively. Hence, from a health economic point of view, the APR was dominant, providing cost saving ICERs from both perspectives.Discussion Following its inception 20+ years ago, the APR has represented excellent value for investment for Australia, being also health-saving and cost saving from a societal and a health care perspective. With the growing number of marketed ASMs, the APR is expected to continue to have a major impact in the foreseeable future.APR=Australian Pregnancy Register; ASM=antiseizure medication; AUD=Australian dollars; ICER=incremental cost-effectiveness ratio; ROI=return on investment; VSLY=value of a statistical life year %U //www.ez-admanager.com/content/neurology/100/10/e1028.full.pdf

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