TY -的T1 - CSF P-Tau181和其他生物标记神经元在细胞核内的夹杂物疾病患者JF -神经学乔-神经病学SP - e1009 LP - e1019做- 10.1212 / WNL。首页0000000000201647六世- 100 - 10盟栗原市Masanori盟——小松Hiroki盟——仙谷由人,Renpei盟——城市涩川市举行的Mari盟森本晃司,Satoru AU -松原科技界盟,荒川晶盟——Orita Makoto AU - Ishibashi吴克群盟——Mitsutake Akihiko盟——柴田Shota盟——Ishiura Hiroyuki AU -足立,薰盟——Ohse Kensuke AU -波多野,Keiko AU - Ihara,恭子非盟- Higashihara魔法盟,仁科靖盟——Tokumaru阿雅美岛绿盟——Ishii吴克群盟——斋藤裕盟——Murayama Shigeo盟——Kanemaru Kazutomi盟——岩田聪,Atsushi Y1 - 2023/03/07 UR - //www.ez-admanager.com/content/100/10/e1009.abstract N2 - CSFτ背景和目标在181苏氨酸磷酸化(p-tau181)是一种广泛使用的生物标志物对阿尔茨海默病(AD)和最近被认为反映β-amyloid和/或p-tau沉积在大脑的广告。首页神经元在细胞核内的包含疾病(相当于卫生部)是一种神经退行性疾病,其特征是在核内包涵体神经元,神经胶质细胞和其他体细胞。症状包括老年痴呆症、神经病变等。脑脊液生物标志物没有报道。本研究的目的是调查是否改变了患者的CSF生物标志物包括p-tau181相当于卫生部。这是一个回顾性观察研究的方法。脑脊液浓度p-tau181,总τ,淀粉样β蛋白1-42 (Aβ42),单胺代谢产物高香草酸(HVA)和5-hydroxyindole乙酸(5-HIAA)之间的比较12日本国家传染病研究所患者120名老年痴呆症患者的临床综合征生物学证实基于脑脊液生物标志物概要文件,以及与其他神经认知障碍患者临床诊断(路易体痴呆与(下文),24;额颞叶痴呆FTD, 13;进行性核上的麻痹(PSP), 21个;和corticobasal综合症(CBS), 13)。 Amyloid PET using Pittsburgh compound B (PiB) was performed in 6 patients with NIID.Results The mean age of patients with NIID, AD, DLB, FTD, PSP, and CBS was 71.3, 74.6, 76.8, 70.2, 75.5, and 71.9 years, respectively. CSF p-tau181 was significantly higher in NIID (72.7 ± 24.8 pg/mL) compared with DLB, PSP, and CBS and was comparable between NIID and AD. CSF p-tau181 was above the cutoff value (50.0 pg/mL) in 11 of 12 patients with NIID (91.7%). Within these patients, only 2 patients showed decreased CSF Aβ42, and these patients showed negative or mild local accumulation in PiB PET, respectively. PiB PET scans were negative in the remaining 4 patients tested. The proportion of patients with increased CSF p-tau181 and normal Aβ42 (A−T+) was significantly higher in NIID (75%) compared with DLB, PSP, and CBS (4.2%, 4.8%, and 7.7%, respectively). CSF HVA and 5-HIAA concentrations were significantly higher in patients with NIID compared with disease controls.Discussion CSF p-tau181 was increased in patients with NIID without amyloid accumulation. Although the deposition of p-tau has not been reported in NIID brains, the molecular mechanism of tau phosphorylation or secretion of p-tau may be altered in NIID.5-HIAA=5-hydroxyindole acetic acid; AD=Alzheimer disease; Aβ42=amyloid-beta 1–42; ANCOVA=analysis of covariance; CBS=corticobasal syndrome; CL=centiloid; DLB=dementia with Lewy bodies; FAB=Frontal Assessment Battery; FXTAS=fragile X-associated tremor/ataxia syndrome; FTD=frontotemporal dementia; HSV-1=herpes simplex virus type 1; HVA=homovanillic acid; MAO=monoaminoxidase; MMSE=Mini-Mental State Examination; NIID=neuronal intranuclear inclusion disease; p-tau181=tau phosphorylated at threonine 181; PiB=Pittsburgh compound B; PSP=progressive supranuclear palsy; t-tau=total tau ER -