RT期刊文章SR电子T1方向性的癫痫症和抑郁症之间的联系乔摩根富林明神经病学神经病学FD Lippincott Williams &威尔金斯SP e932 OP e942 10.1212 / WNL。首页100签证官0000000000201542是9 A1 Eva Bølling-Ladegaard A1朱莉Werenberg德雷尔A1 Lars Vedel凯斯A1 Esben Budtz-Jørgensen A1 Kasper Lolk A1雅各布·克里斯滕森年2023 UL //www.ez-admanager.com/content/100/9/e932.首页abstract AB背景和目标癫痫症和抑郁症有着双向的关系;然而,它的大小和长期时间协会仍有待阐明。这项研究调查了大小和长期癫痫与抑郁症之间的联系,与这两种疾病的风险又一个慢性疾病(哮喘)。方法在全国范围内寄存器的匹配的队列研究中,我们发现所有人收到第一诊断为癫痫,抑郁,和哮喘从1980年1月1日至12月31日,2016年。我们使用Cox回归模型来估计癫痫后抑郁的风险,反之亦然,癫痫或抑郁后哮喘的风险,而健康的引用在年龄和性别匹配,调整医疗疾病,药物滥用,和日历时间。结果被癫痫亚型分层。我们进一步研究了录取的风险与癫痫急性发作的人变得消沉。导致人口8741955人,我们确定了139014人与癫痫诊断(54%的男性,平均年龄在43年(内部四分位范围(差)17 - 65年]),219990人患抑郁症(37%的男性,平均年龄在43年诊断[差29-60年]),和358821人患有哮喘诊断(49%的男性,平均年龄在29年[差6-56年])。患抑郁症的风险比(aHR)调整后癫痫为1.88 (95% CI 1.82 - -1.95),和癫痫后抑郁症的aHR是2.35 (95% CI 2.25 - -2.44)。 The aHR of depression after asthma was 1.63 (95% CI 1.59–1.67) and that of epilepsy after asthma, 1.48 (95% CI 1.44–1.53). The risk of depression was highest in the few years preceding and after an epilepsy diagnosis, and vice versa, but remained elevated during the entire follow-up period for both directions of the association. There was no evidence of a stronger association with depression for any epilepsy subtype. Receiving a diagnosis of depression subsequent to an epilepsy diagnosis was associated with a 1.20-fold (95% CI 1.07–1.36) increased HR of acute hospital admission with seizures.Discussion We identified a long-term bidirectional relationship between depression and epilepsy in a large-scale cohort study. Risk estimates were higher than those of epilepsy or depression after asthma.aHR=adjusted HR; aOR=adjusted OR; CCI=Charlson comorbidity index; DCPR=Danish Central Psychiatric Register; DNPR=Danish National Patient Registry; HR=hazard ratio; ICD-8=International Classification of Diseases, eighth revision; ICD-10=International Classification of Diseases, 10th revision; OR=odds ratio; PPV=positive predictive value