作者@article {B {\ o} lling-Ladegaarde932 = {Eva B {\ o} lling-Ladegaard和朱莉Werenberg德雷尔和Lars Vedel凯斯和Esben Budtz-J {\ o} rgensen Kasper Lolk和雅各布·克里斯滕森},title ={方向性的癫痫症和抑郁症之间的关系},体积={100}={9},页面= {e932——e942} = {2023}, doi = {10.1212 / WNL。出版商0000000000201542}= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={背景和目标癫痫症和抑郁症有着双向的关系;首页然而,它的大小和长期时间协会仍有待阐明。这项研究调查了大小和长期癫痫与抑郁症之间的联系,与这两种疾病的风险又一个慢性疾病(哮喘)。方法在全国范围内寄存器的匹配的队列研究中,我们发现所有人收到第一诊断为癫痫,抑郁,和哮喘从1980年1月1日至12月31日,2016年。我们使用Cox回归模型来估计癫痫后抑郁的风险,反之亦然,癫痫或抑郁后哮喘的风险,而健康的引用在年龄和性别匹配,调整医疗疾病,药物滥用,和日历时间。结果被癫痫亚型分层。我们进一步研究了录取的风险与癫痫急性发作的人变得消沉。导致人口8741955人,我们确定了139014人与癫痫诊断(54 \ %的男性,平均年龄在43年(内部四分位范围(差)17 {\ textendash} 65年]),219990人患抑郁症诊断(37 \ %的男性,平均年龄在43年(IQR 29 {\ textendash} 60年)),和358821人患有哮喘诊断(49 \ %的男性,平均年龄在29年(IQR 6 {\ textendash} 56年))。患抑郁症的风险比(aHR)调整后癫痫是1.88 (95 \ % CI 1.82 {\ textendash} 1.95),和癫痫后抑郁症的aHR是2.35 (95 \ % CI 2.25 {\ textendash} 2.44)。后抑郁症的哮喘气道高反应性为1.63 (95 \ % CI 1.59 {\ textendash} 1.67)和癫痫后哮喘,1.48 (95 \ % CI 1.44 {\ textendash} 1.53)。 The risk of depression was highest in the few years preceding and after an epilepsy diagnosis, and vice versa, but remained elevated during the entire follow-up period for both directions of the association. There was no evidence of a stronger association with depression for any epilepsy subtype. Receiving a diagnosis of depression subsequent to an epilepsy diagnosis was associated with a 1.20-fold (95\% CI 1.07{\textendash}1.36) increased HR of acute hospital admission with seizures.Discussion We identified a long-term bidirectional relationship between depression and epilepsy in a large-scale cohort study. Risk estimates were higher than those of epilepsy or depression after asthma.aHR=adjusted HR; aOR=adjusted OR; CCI=Charlson comorbidity index; DCPR=Danish Central Psychiatric Register; DNPR=Danish National Patient Registry; HR=hazard ratio; ICD-8=International Classification of Diseases, eighth revision; ICD-10=International Classification of Diseases, 10th revision; OR=odds ratio; PPV=positive predictive value}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/100/9/e932}, eprint = {//www.ez-admanager.com/content/100/9/e932.full.pdf}, journal = {Neurology} }