% 0期刊文章% Gabriel Broocks %卢卡斯Meyer %一个罗莎莉麦克多诺萨拉曾% %一个Matthias贝希施泰因% Tobias Djamsched Faizy %彼得•斯波恩%格哈德•舍恩%一个Jens Minnerup % Helge c . Kniep % Uta汉宁%一个Ewgenia Barow %一个彼得·施拉姆% Soenke兰纳%喋喋不休Nawabi %一个Panagiotis Papanagiotou % Maarten Max Wintermark % g·Lansberg %一个杰里米·j·海特格雷戈里•阿尔伯斯(george w . bush) % %一个安德烈Kemmling Jens Fiehler % %和我上次调查者% T净水吸收之间的联系和功能结果脑损伤患者的低方面% B从我上次研究的结果% D R 10.1212 / WNL 2023%。0000000000201601 % J首页神经病学% P e954-e963 % V 100% N 9% X背景和目标的影响机械血栓切除术(MT)功能结果缺血性中风患者较低的方面仍然是不确定的。方面的评级是基于存在缺血性hypoattenuation相对正常;然而,hypoattenuation的程度,直接反映净吸收的水,目前不考虑成像中风诊断的生物标志物。我们假设的影响血栓切除术患者功能结果在低方面取决于早期病变水吸收。方法多中心观察研究,前循环中风患者方面≤5进行了连续分析。净水吸收(NWU)被评估为入学CT定量成像生物标志物。主要终点是良好的功能结果的速度定义为改良Rankin量表得分0 - 3天90。血管再通的影响功能的结果分析了根据NWU在梗塞早期病变的程度。结果共有254名患者,其中148例(58%)进行了太方面中值为4(四分位范围(差)3 - 5),和NWU中值为11.4%(差8.9%—-15.1%)。有利的结果是27.6%的病人NWU较低(< 11.4%)与6.3%患者高NWU (≥11.4%; p < 0.0001). In multivariable logistic regression analysis, NWU was an independent predictor of outcome, whereas vessel recanalization (modified thrombolysis in cerebral infarction ≥2b) was only significantly associated with better outcomes if NWU was lower than 12.6%. In inverse-probability weighting analysis, recanalization was associated with 20.7% (p = 0.01) increase in favorable outcome in patients with low NWU compared with 9.1% (p = 0.06) in patients with high NWU.Discussion Early NWU was independently associated with clinical outcome and might serve as an indicator of futile MT in low ASPECTS patients. NWU could be tested as a tool to select low ASPECTS patients for MT.Trial Registration Information The study is registered within the ClinicalTrials.gov Protocol Registration and Results System (NCT04862507).aOR=adjusted odds ratio; AUC=area under the curve; CTP=perfusion CT; HU=Hounsfield unit; IPW=inverse probability weighting; IQR=interquartile range; MT=mechanical thrombectomy; mTICI=modified thrombolysis in cerebral infarction; NECT=nonenhanced CT; NIHSS=NIH Stroke Scale; NWU=net water uptake; PH=parenchymal hematoma; ROI=region of interest %U //www.ez-admanager.com/content/neurology/100/9/e954.full.pdf