TY -的T1 -净水吸收之间的联系和功能结果脑损伤患者的低方面JF -神经学乔-神经病学SP - e954 LP - e963做- 10.1212 / WNL。首页0000000000201601六世- 100 - 9 AU -加布里埃尔Broocks盟-卢卡斯Meyer盟-萨拉曾AU -罗莎莉麦克多诺盟Matthias贝希施泰因盟Tobias Djamsched Faizy AU -彼得·斯波恩盟格哈德•绍恩盟Jens Minnerup AU -赫尔格·c·Kniep盟Uta汉宁非盟- Ewgenia Barow AU -彼得·施拉姆盟Soenke兰纳盟喋喋不休Nawabi AU - Panagiotis Papanagiotou AU - Max Wintermark盟Maarten g . Lansberg AU -格里高利·w·阿尔伯斯盟-杰里米·j·海特盟Jens Fiehler AU -安德烈Kemmling盟,我上次调查人员Y1 - 2023/02/28 UR - //www.ez-admanager.com/content/100/9/e954.abstract N2 -背景和目标的影响机械血栓切除术(MT)功能结果缺血性中风患者较低的方面仍然是不确定的。首页方面的评级是基于存在缺血性hypoattenuation相对正常;然而,hypoattenuation的程度,直接反映净吸收的水,目前不考虑成像中风诊断的生物标志物。我们假设的影响血栓切除术患者功能结果在低方面取决于早期病变水吸收。方法多中心观察研究,前循环中风患者方面≤5进行了连续分析。净水吸收(NWU)被评估为入学CT定量成像生物标志物。主要终点是良好的功能结果的速度定义为改良Rankin量表得分0 - 3天90。血管再通的影响功能的结果分析了根据NWU在梗塞早期病变的程度。结果共有254名患者,其中148例(58%)进行了太方面中值为4(四分位范围(差)3 - 5),和NWU中值为11.4%(差8.9%—-15.1%)。 The rate of favorable outcome was 27.6% in patients with low NWU (<11.4%) vs 6.3% in patients with high NWU (≥11.4%; p < 0.0001). In multivariable logistic regression analysis, NWU was an independent predictor of outcome, whereas vessel recanalization (modified thrombolysis in cerebral infarction ≥2b) was only significantly associated with better outcomes if NWU was lower than 12.6%. In inverse-probability weighting analysis, recanalization was associated with 20.7% (p = 0.01) increase in favorable outcome in patients with low NWU compared with 9.1% (p = 0.06) in patients with high NWU.Discussion Early NWU was independently associated with clinical outcome and might serve as an indicator of futile MT in low ASPECTS patients. NWU could be tested as a tool to select low ASPECTS patients for MT.Trial Registration Information The study is registered within the ClinicalTrials.gov Protocol Registration and Results System (NCT04862507).aOR=adjusted odds ratio; AUC=area under the curve; CTP=perfusion CT; HU=Hounsfield unit; IPW=inverse probability weighting; IQR=interquartile range; MT=mechanical thrombectomy; mTICI=modified thrombolysis in cerebral infarction; NECT=nonenhanced CT; NIHSS=NIH Stroke Scale; NWU=net water uptake; PH=parenchymal hematoma; ROI=region of interest ER -