RT期刊文章SR电子T1处理延迟或错过剂量的抗癫痫药物摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP e921 OP e931 10.1212 / WNL。首页100签证官0000000000201604是9 A1 Zi-ran李A1陈钰王A1萎萎林A1 Yue-ting陈A1 xiao qin刘A1郑娇年2023 UL //www.ez-admanager.com/content/100/9/e921.abstract AB背景和目标首页推迟或错过了抗癫痫药物(asm)在长期或终身antiepilepsy治疗剂量是很常见的。本研究旨在探讨最佳的个性化治疗剂量方案推迟或错过剂量的11常用的asm。方法探索治疗剂量方案,使用蒙特卡罗模拟基于之前确定并公布人口药代动力学模型。六个补救策略推迟或错过剂量。个人治疗范围外的偏差的时间被用来评估每个补救方案。的影响病人的人口统计、处方药和预定剂量间隔补救方案进行评估。RxODE和闪亮的R被用来进行蒙特卡罗模拟和推荐个人补救方案。结果建议补救方案是高度相关的延迟时间,预定的剂量间隔和ASM的半衰期。此外,儿童和成人患者的最佳治疗方案是不同的。 The renal function, along with concomitant medication that affects the clearance of the ASM, may also influence the remedial regimens. A web-based dashboard was developed to provide individualized remedial regimens for the delayed or missed dose, and a user-defined module with all parameters that could be defined flexibly by the user was also built.Discussion Monte Carlo simulation based on population pharmacokinetic models may provide a rational approach to propose remedial regimens for delayed or missed doses of ASMs in pediatric and adult patients with epilepsy.ASM=antiseizure medication; FDA=US Food and Drug Administration; PK=pharmacokinetic