PT -期刊文章盟Zi-ran李盟- Chen yu王盟萎萎林盟- Yue-ting陈盟xiao qin刘盟-郑娇TI -处理延迟或错过剂量的抗癫痫药物援助- 10.1212 / WNL。0000000000201604 DP - 2023年2月28日TA -神经病首页学PG - e921 e931 VI - 100 IP - 9 4099 - //www.ez-admanager.com/content/100/9/e921.short 4100 - //www.ez-admanager.com/content/100/9/e921.full所以Neurology2023 2月28日;100 AB -背景和目标推迟或错过了抗癫痫药物(asm)在长期或终身antiepilepsy治疗剂量是很常见的。本研究旨在探讨最佳的个性化治疗剂量方案推迟或错过剂量的11常用的asm。方法探索治疗剂量方案,使用蒙特卡罗模拟基于之前确定并公布人口药代动力学模型。六个补救策略推迟或错过剂量。个人治疗范围外的偏差的时间被用来评估每个补救方案。的影响病人的人口统计、处方药和预定剂量间隔补救方案进行评估。RxODE和闪亮的R被用来进行蒙特卡罗模拟和推荐个人补救方案。结果建议补救方案是高度相关的延迟时间,预定的剂量间隔和ASM的半衰期。 Moreover, the optimal remedial regimens for pediatric and adult patients were different. The renal function, along with concomitant medication that affects the clearance of the ASM, may also influence the remedial regimens. A web-based dashboard was developed to provide individualized remedial regimens for the delayed or missed dose, and a user-defined module with all parameters that could be defined flexibly by the user was also built.Discussion Monte Carlo simulation based on population pharmacokinetic models may provide a rational approach to propose remedial regimens for delayed or missed doses of ASMs in pediatric and adult patients with epilepsy.ASM=antiseizure medication; FDA=US Food and Drug Administration; PK=pharmacokinetic