% 0期刊文章%一个李Zi-ran %陈钰王%萎萎林% Yue-ting陈% xiao qin刘%郑娇% T处理延迟或错过了% B Model-Informed个人剂量的抗癫痫药物治疗剂量% D R 10.1212 / WNL 2023%。0000000000201604 % J首页神经病学% P e921-e931 % V 100% N 9% X背景和目标推迟或错过了抗癫痫药物(asm)在长期或终身antiepilepsy治疗剂量是很常见的。本研究旨在探讨最佳的个性化治疗剂量方案推迟或错过剂量的11常用的asm。方法探索治疗剂量方案,使用蒙特卡罗模拟基于之前确定并公布人口药代动力学模型。六个补救策略推迟或错过剂量。个人治疗范围外的偏差的时间被用来评估每个补救方案。的影响病人的人口统计、处方药和预定剂量间隔补救方案进行评估。RxODE和闪亮的R被用来进行蒙特卡罗模拟和推荐个人补救方案。结果建议补救方案是高度相关的延迟时间,预定的剂量间隔和ASM的半衰期。此外,儿童和成人患者的最佳治疗方案是不同的。肾功能以及伴随药物影响ASM的间隙,也可能影响补救方案。 A web-based dashboard was developed to provide individualized remedial regimens for the delayed or missed dose, and a user-defined module with all parameters that could be defined flexibly by the user was also built.Discussion Monte Carlo simulation based on population pharmacokinetic models may provide a rational approach to propose remedial regimens for delayed or missed doses of ASMs in pediatric and adult patients with epilepsy.ASM=antiseizure medication; FDA=US Food and Drug Administration; PK=pharmacokinetic %U //www.ez-admanager.com/content/neurology/100/9/e921.full.pdf