@article {Lie921作者= {Zi-ran李和Chen yu王、林萎萎Yue-ting陈和刘xiao qin郑娇},title ={处理延迟或错过剂量的抗癫痫药物},体积={100}={9},页面= {e921——e931} = {2023}, doi = {10.1212 / WNL。出版商0000000000201604}= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={背景和目标推迟或错过了抗癫痫药物(asm)在长期或终身antiepilepsy首页治疗剂量是很常见的。本研究旨在探讨最佳的个性化治疗剂量方案推迟或错过剂量的11常用的asm。方法探索治疗剂量方案,使用蒙特卡罗模拟基于之前确定并公布人口药代动力学模型。六个补救策略推迟或错过剂量。个人治疗范围外的偏差的时间被用来评估每个补救方案。的影响患者{\ textquoteright}人口,处方药,预定剂量间隔补救方案进行评估。RxODE和闪亮的R被用来进行蒙特卡罗模拟和推荐个人补救方案。结果建议补救方案是高度相关的延迟时间,预定的剂量间隔和ASM的半衰期。此外,儿童和成人患者的最佳治疗方案是不同的。肾功能以及伴随药物影响ASM的间隙,也可能影响补救方案。 A web-based dashboard was developed to provide individualized remedial regimens for the delayed or missed dose, and a user-defined module with all parameters that could be defined flexibly by the user was also built.Discussion Monte Carlo simulation based on population pharmacokinetic models may provide a rational approach to propose remedial regimens for delayed or missed doses of ASMs in pediatric and adult patients with epilepsy.ASM=antiseizure medication; FDA=US Food and Drug Administration; PK=pharmacokinetic}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/100/9/e921}, eprint = {//www.ez-admanager.com/content/100/9/e921.full.pdf}, journal = {Neurology} }