RT期刊文章SR电子T1英国生物银行参与者定期使用通便剂与痴呆事件之间的关联JF神经病学JO神经病学FD Lippincott Williams & Wilkins SP 10.1212/WNL.0000000000207081首页10.1212 / WNL.0000000000207081A1杨志荣A1常伟A1李晓娟A1袁金秋A1高雪峰A1李冰玉A1赵子怡A1杜森威A1于鑫A1 Carol Brayne A1杨祖耀A1冯莎A1唐金玲YR 2023 UL //www.ez-admanager.com/content/early/2023/02/22/WNL.0000000000207081.abstract AB背景和目标非处方泻药的使用在一般人群中很常见。首页微生物群-肠道-脑轴假说表明，服用泻药与痴呆症有关。我们旨在研究英国生物银行参与者中定期使用泻药与痴呆症发病率之间的关系。这项前瞻性队列研究基于英国生物银行参与者，年龄在40岁至69岁之间，无痴呆史。常规使用泻药的定义为基线时(2006-2010年)过去4周内每周大部分时间自我报告使用泻药。结果是全因痴呆、阿尔茨海默病和血管性痴呆，从相关住院或死亡登记中确定(截至2020年)。在多变量Cox回归分析中，对社会人口学特征、生活方式因素、医疗条件、家族史和常规用药进行了调整。在基线时平均年龄为56.5岁(SD=8.1)的502229名参与者中，273,251名(54.4%)为女性，18,235名(3.6%)报告经常使用泻药。在平均9.8年的随访中，218名(1.3%)经常服用泻药的参与者和1969名(0.4%)不经常服用泻药的参与者患上了全因痴呆。 Multivariable analyses showed that regular use of laxatives was associated with increased risk of all-cause dementia (hazard ratio [HR] 1.51; 95% confidence interval 1.30-1.75) and vascular dementia (HR 1.65; 1.21-2.27), with no significant association observed for Alzheimer’s disease (HR 1.05; 0.79-1.40). The risk of both all-cause dementia and vascular dementia increased with the number of regularly used laxative types (P-trend 0.001 and 0.04, respectively). Among the participants who clearly reported that they were using just one type of laxative (n=5800), only those using osmotic laxatives showed a statistically significantly higher risk of all-cause dementia (HR 1.64 [1.20-2.24]) and vascular dementia (HR 1.97 [1.04-3.75]). These results remained robust in various subgroup and sensitivity analyses.Discussion Regular use of laxatives was associated with a higher risk of all-cause dementia, particularly in those who used multiple laxative types or osmotic laxative.

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