女性偏头痛患者的性激素和降钙素基因相关肽:一项横断面、匹配队列研究[j]首页10.1212 / WNL.0000000000207114背景和目的:性激素可能调节三叉神经血管系统中CGRP的释放。首页我们研究了患有发作性偏头痛(EM)和月经周期正常(RMC)的女性受试者、患有EM和联合口服避孕药(COC)的女性受试者以及绝经后患有EM的女性受试者血浆和泪液中的CGRP浓度。作为对照，我们分析了三组年龄相匹配的女性受试者。方法:RMC受试者在月经周期第2±2天和排卵期第13±2天两次就诊。COC患者在无激素间隔(HFI)的第4±2天和激素摄入(HI)的第7-14天进行检查。绝经后参与者在随机时间点评估一次。每次就诊时收集血浆和泪液样本，用酶联免疫吸附法测定CGRP水平。结果:共有180名女性参与者(每组30人)完成了研究。与没有偏头痛的女性受试者相比，偏头痛和RMC患者在月经期间血浆和泪液中的CGRP浓度有统计学意义上显著升高[血浆:5.95 pg/ml (IQR 4.37 - 10.44) vs. 4.61 pg/ml (IQR 2.83 - 6.92)， p=0.020 (Mann-Whitney U检验);泪液:1.20 ng/ml (IQR 0.36 ~ 2.52) vs. 0.4 ng/ml (IQR 0.14 ~ 1.22)， p=0.005 (Mann-Whitney U检验)。 In contrast, female participants with COC and in the postmenopause had similar CGRP levels in the migraine and the control groups. In migraine participants with a RMC, tear fluid but not plasma CGRP concentrations during menstruation were statistically significantly higher compared to migraine participants under COC (p=0.015 vs. HFI and p=0.029 vs. HI, Mann-Whitney U test).Discussion: Different sex hormone profiles may influence CGRP concentrations in people, with current or past capacity to menstruate, with migraine. Measurement of CGRP in tear fluid was feasible and warrants further investigation.