新冠肺炎确诊后前6个月癫痫和癫痫发作的发生率[j]神经病学，神经病学，Lippincott Williams & Wilkins SP e790 OP e799 DO 10.1212/WNL.0000000000201595首页VO 100 IS 8 A1 Maxime Taquet A1 Orrin Devinsky A1 J. Helen Cross A1 Paul J. Harrison A1 Arjune Sen YR 2023 UL http://n.首页neurology.org/content/100/8/e790.abstract AB背景与目的COVID-19与癫痫的关系尚不确定。我们研究了COVID-19与感染后6个月内癫痫发作或癫痫之间的潜在关联。我们将验证方法应用于一个包含8100万人的电子健康记录网络(TriNetX Analytics)。我们将COVID-19感染者与流感患者密切匹配。在每个队列中，我们测量了癫痫发作和癫痫的发生率和风险比(hr)。我们根据年龄和患者在急性感染期间是否住院对数据进行分层。然后，我们探索时变hr来评估癫痫发作或癫痫诊断的时间模式。结果共分析了860,934份电子病历。匹配后，这产生了两个队列，每个队列有152,754名患者。与流感相比，COVID-19与癫痫发作风险增加有关。 The incidence of seizures within 6 months of COVID-19 was 0.81% (95% CI 0.75–0.88; HR compared with influenza 1.55 [1.39–1.74]). The incidence of epilepsy was 0.30% (0.26–0.34; HR compared with influenza 1.87 [1.54–2.28]). The HR of epilepsy after COVID-19 compared with influenza was greater in people who had not been hospitalized and in individuals younger than 16 years. The time of peak HR after infection differed by age and hospitalization status.Discussion The incidence of new seizures or epilepsy diagnoses in the 6 months after COVID-19 was low overall, but higher than in matched patients with influenza. This difference was more marked in people who were not hospitalized, highlighting the risk of epilepsy and seizures even in those with less severe infection. Children appear at particular risk of seizures and epilepsy after COVID-19 providing another motivation to prevent COVID-19 infection in pediatric populations. That the varying time of peak risk related to hospitalization and age may provide clues as to the underlying mechanisms of COVID-associated seizures and epilepsy.CPT=Current Procedural Terminology; HRs=hazard ratios; HCOs=healthcare organizations; ICD=International Classification of Diseases; PNES=psychological nonepileptic attacks

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