PT -期刊文章AU - Maxime Taquet AU - Orrin Devinsky AU - J. Helen Cross AU - Paul J. Harrison AU - Arjune Sen TI - COVID-19诊断后前6个月内癫痫和癫痫发作的发生率- 10.1212/WNL.0000000000201595DP - 2023 2月21日TA -神经学首页PG - e790- e799 VI - 100 IP - 8 4099 - //www.ez-admanager.com/content/100/8/e790.short 4100 - //www.ez-admanager.com/content/100/8/e790.full SO -神经学2023 2月21日;背景和目标COVID-19与癫痫之间的关系尚不确定。我们研究了感染后6个月内COVID-19与癫痫发作或癫痫之间的潜在关联。我们将验证过的方法应用于8100万人的电子健康记录网络(TriNetX Analytics)。我们将COVID-19感染者与流感患者密切匹配。在每个队列中，我们测量了癫痫发作和癫痫的发病率和危险比(HRs)。我们将数据按年龄和急性感染期间是否住院进行分层。然后，我们探索随时间变化的HRs来评估癫痫发作或癫痫诊断的时间模式。结果:我们分析了860934份电子健康记录。在匹配后，产生了两个队列，每个队列152,754名患者。 COVID-19 was associated with an increased risk of seizures and epilepsy compared with influenza. The incidence of seizures within 6 months of COVID-19 was 0.81% (95% CI 0.75–0.88; HR compared with influenza 1.55 [1.39–1.74]). The incidence of epilepsy was 0.30% (0.26–0.34; HR compared with influenza 1.87 [1.54–2.28]). The HR of epilepsy after COVID-19 compared with influenza was greater in people who had not been hospitalized and in individuals younger than 16 years. The time of peak HR after infection differed by age and hospitalization status.Discussion The incidence of new seizures or epilepsy diagnoses in the 6 months after COVID-19 was low overall, but higher than in matched patients with influenza. This difference was more marked in people who were not hospitalized, highlighting the risk of epilepsy and seizures even in those with less severe infection. Children appear at particular risk of seizures and epilepsy after COVID-19 providing another motivation to prevent COVID-19 infection in pediatric populations. That the varying time of peak risk related to hospitalization and age may provide clues as to the underlying mechanisms of COVID-associated seizures and epilepsy.CPT=Current Procedural Terminology; HRs=hazard ratios; HCOs=healthcare organizations; ICD=International Classification of Diseases; PNES=psychological nonepileptic attacks