TY -的T1 - NIH工具箱来检测认知变化的敏感性个体智力和发育障碍JF -神经学乔-神经病学SP - e778 LP - e789做- 10.1212 / WNL。首页0000000000201528六世- 100 - 8 AU -丽贝卡·h·盾牌AU -亚伦Kaat盟-斯蒂芬妮·m·桑松AU -克莱尔的旧事盟珍妮科尔曼盟-汤普森塔里亚盟-福勒斯特·j·麦肯齐盟-安德鲁Dakopolos AU - Karen Riley AU -伊丽莎白Berry-Kravis AU -基思·f·Widaman AU - Richard c .革顺盟大卫Hessl Y1 - 2023/02/21 UR - //www.ez-admanager.com/content/100/8/e778.abstract N2 -背景和客观的个人经验智力残疾(ID)旷日持久的认知发展与典型的青年。首页敏感测量认知变化的人口是一个重要的临床试验的必要性和其他干预研究,但结果有效的措施是稀缺的。本研究的目的是评估的灵敏度NIH工具箱认知电池(NIHTB-CB)检测发展变化组与ID-fragile X综合征(FXS),唐氏综合症(DS)和其他ID (OID)——提供进一步支持它的使用作为一个结果测量治疗试验。方法我们管理NIHTB-CB和参考标准交叉验证测量(斯坦福-比奈智力量表,第五版[SB5])与FXS 256人,DS和OID(6-27岁)。经过2年的发展,我们重新测试197个人。集团发展变化在每一个认知域的NIHTB-CB和SB5评估使用潜在改变评分模型,和2年增长评估岁3分(10、16和22年)。结果总的来说,影响大小的增长来衡量NIHTB-CB试验是相当或超过SB5。NIHTB-CB显示显著收益在几乎所有领域OID在年轻的年龄(10年),在16年持续增长和稳定在成年早期(22岁)。FXS组显示延迟的关注和抑制性控制而OID。DS组延迟接受性词汇的收益而OID。不同于其他群体,DS在成年早期显著增长2域(工作记忆和注意力/抑制性控制)。 Notably, each group's pattern of NIHTB-CB growth across development corresponded to their respective pattern of SB5 growth.Discussion The NIHTB-CB is sensitive to developmental changes in individuals with ID. Comparison with levels and timing of growth on the cross-validation measure shows that the NIHTB-CB has potential to identify meaningful trajectories across cognitive domains and ID etiologies. Sensitivity to change within the context of treatment studies and delineation of clinically meaningful changes in NIHTB-CB scores, linked to daily functioning, must be established in future research to evaluate the battery more completely as a key outcome measure.CSS=change sensitive score; DCCS=Dimensional Change Card Sort; DS=Down syndrome; DSM-5=Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition; EGCG=epigallocatechin-3-gallate; FICA=Flanker Inhibitory Control and Attention; FSIQ=Full Scale IQ; FXS=fragile X syndrome; ID=intellectual disability; LSWM=List Sorting Working Memory; NIHTB-CB=NIH Toolbox Cognition Battery; OID=other ID; ORR=Oral Reading Recognition; PCPS=Pattern Comparison Processing Speed; PDE4=phosphodiesterase-4D; PSM=Picture Sequence Memory; PV=Picture Vocabulary; SB5=Stanford-Binet Intelligence Scales, Fifth Edition; USS=uncorrected standard score ER -