PT -期刊文章盟劳埃德·普罗塞非盟-艾米Macdougall AU -卡罗尔h . Sudre盟-艾米丽·n·曼宁AU -伊恩·b·马龙AU -菲比沃尔什盟-奥利维亚Goodkin AU -休·彭伯顿盟弗雷德里克Barkhof AU -基尔特•简•Biessels盟David m .现金AU -约瑟芬巴恩斯盟的阿尔茨海默病的神经影像学TI -使用基线指标预测老年人认知衰退的广告病态,脑血管疾病和神经退行性变的援助- 10.1212 / WNL。0000000000201572 DP - 2023年2月21日TA -神经病首页学PG - e834 e845 VI - 100 IP - 8 4099 - //www.ez-admanager.com/content/100/8/e834.short 4100 - //www.ez-admanager.com/content/100/8/e834.full所以Neurology2023 2月21日;100 AB -痴呆是一个日益严重的社会经济背景和目标的挑战,需要早期干预。标志物,可靠地预测在疾病的早期临床进展过程更好的援助的选择个人未来审判参与。在这里,我们的能力基线相比,单一时间点生物标志物(CSF淀粉样1-42,CSF ptau - 181,白质hyperintensities(负责人),脑microbleeds,全脑体积,和海马体积)来预测个体认知正常下降后转换为轻度认知障碍(MCI) (CNtoMCI)和MCI后来转换为一个阿尔茨海默病(AD)的诊断(MCItoAD)。生物标记方法标准化的基线数据从广告神经影像倡议2 (ADNI2) /去纵向诊断数据(包括ADNI3)。Cox回归模型评估生物标志物与临床诊断时间变化使用所有可用随访时间点。模型适合生物标记一起单变量和多变量模型。风险比率(小时)进行比较来评估生物标志物。在CNtoMCI和MCItoAD组分别分析。结果CNtoMCI (n = 189),有强有力的证据表明,更高的负责人卷(个人模式:人力资源1.79,p = 0.002;全面调整模式:人力资源1.98,p = 0.003)和降低海马体积(个人:人力资源0.54,p = 0.001; fully adjusted: HR 0.40, p < 0.001) were associated with conversion to MCI individually and independently. For MCItoAD (n = 345), lower hippocampal (individual model: HR 0.45, p < 0.001; fully adjusted model: HR 0.55, p < 0.001) and whole-brain volume (individual: HR 0.31, p < 0.001; fully adjusted: HR 0.48, p = 0.02), increased CSF ptau (individual: HR 1.88, p < 0.001; fully adjusted: HR 1.61, p < 0.001), and lower CSF amyloid (individual: HR 0.37, p < 0.001; fully adjusted: HR 0.62, p = 0.008) were most strongly associated with conversion to AD individually and independently.Discussion Lower hippocampal volume was a consistent predictor of clinical conversion to MCI and AD. CSF and brain volume biomarkers were predictive of conversion to AD from MCI, whereas WMH were predictive of conversion to MCI from cognitively normal. The predictive ability of WMH in the CNtoMCI group may be interpreted as some being on a different pathologic pathway, such as vascular cognitive impairment.AD=Alzheimer disease; ADNI=Alzheimer's Disease Neuroimaging Initiative; CDR=Clinical Dementia Rating; CMB=cerebral microbleeds; CN=cognitively normal; CVD=cerebrovascular disease; HR=hazard ratio; MCI=mild cognitive impairment; MMSE=Mini-Mental State Examination; SMC=significant memory concern; WMH=white matter hyperintensities; TIV=total intracranial volume