TY - T1的白色脂肪组织对大脑结构的影响,灌注,严重肥胖患者的认知功能JF -神经学乔-神经病学SP - e703 LP - e718做- 10.1212 / WNL。首页0000000000201538六世- 100 - 7非盟-黛比Vreeken盟Florine塞德尔非盟-圭多de La Roij盟Wouter ven盟——威廉。a .窝Hengst AU - Lars Verschuren盟Serdar Ozsezen AU -罗伊pc kessel盟马可duer盟Henk J.M.M. Mutsaerts AU -罗伯特Kleemann盟马克西米利安Wiesmann AU - Eric j . Hazebroek盟阿曼达·j·Kiliaan Y1 - 2023/02/14 UR - //www.ez-admanager.com/content/100/7/e703.abstract N2 -背景和客观而潜在的病理生理学肥胖与大脑健康并不是完全理解,白色脂肪组织(窟)被认为是一个关键的球员。首页在肥胖、窟变得特异表达,显示增生、肥大,最终炎症。这种不平衡会导致发病的分泌影响特异表达(有氧运动)血管和大脑健康。在这项研究中,我们调查了网膜的窟(oWAT)之间的联系和皮下窟(scWAT)与大脑结构和严重肥胖成人灌注和认知。在横断面BARICO方法研究中,大脑结构和灌注和认知功能是测量前减肥手术(BS)使用MRI和认知评估。在BS, oWAT和scWAT仓库被组织病理学收集和分析。脂肪细胞的数量和直径是量化的数量一起冠状结构(CLS)作为炎症的迹象。收集血液样本,分析发病和炎症标记物。神经影像学结果包括脑容量、皮质厚度、白质(WM)的完整性,WM hyperintensities,脑血流量使用动脉自旋标记(ASL)和美国手语空间变异系数(sCoV),反映脑血管的健康。结果七十一例患者中(平均年龄45.1±5.8年;83.1%的女性; mean body mass index 40.8 ± 3.8 kg/m2). scWAT showed more CLS (z = −2.72, p < 0.01, r = −0.24) and hypertrophy compared with oWAT (F(1,64) = 3.99, p < 0.05, η2 = 0.06). Adiponectin levels were inversely associated with the average diameter of scWAT (β = −0.31, 95% CI −0.54 to −0.08) and oWAT (β = −0.33, 95% CI −0.55 to −0.09). Furthermore, the adipocyte diameter in oWAT was positively associated with the sCoV in the parietal cortex (β = 0.33, 95% CI 0.10–0.60), and the number of adipocytes (per mm2) was positively associated with sCoV in the nucleus accumbens (NAcc) (β = 0.34, 95% CI 0.09–0.61). Cognitive function did not correlate with any WAT parameter or plasma marker. These associations were highly influenced by age and sex. sCoV in the NAcc was positively associated with fasting plasma glucose (β = 0.35, 95% CI 0.10–0.56).Discussion scWAT and oWAT are different in morphology and in their relationship with plasma markers and cerebrovascular health. Although scWAT showed more CLS and hypertrophy, scWAT was not associated with brain readouts. This study showed, however, important relationships between oWAT morphology and cerebrovascular health in obesity.Trial Registration Information Trial Registration Number NTR7288 (trialregister.nl/trial/7090).ASL=arterial spin labeling; ATT=arterial transit time; BMI=body mass index; BS=bariatric surgery; CBF=cerebral blood flow; COWAT=Controlled Word Association Test; CLS=crown-like structure; CRP=C-reactive protein; DWI=diffusion-weighted imaging; ELISAs=enzyme-linked immunosorbent assays; FPG=fasting plasma glucose; FLAIR=fluid-attenuated inversion recovery; GM=gray matter; HbA1c=hemoglobin A1c; ICV=intracranial volume; IQR=interquartile range; IL-6=interleukin-6; MoCA=Montreal Cognitive Assessment; MSMD=mean skeletonized mean diffusivity; nAcc=nucleus accumbens; ns=not significant; oWAT=omental WAT; ROI=region of interest; sCoV=spatial coefficient of variation; scWAT=Subcutaneous WAT; SAA=serum amyloid A; SIMOA=single-molecule array; TE=echo time; TI=inversion time; TR=repetition time; TAP=Test of Attentional Performance; TNF-α=tumor necrosis factor alpha; vWAT=visceral WAT; WAT=white adipose tissue; WC=waist circumference; WM=white matter; WMH=white matter hyperintensity ER -