RT期刊文章SR电子T1脑脊液流动和脊髓运动自发性颅内低血压患者摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP e651 OP e660 10.1212 / WNL。首页100签证官0000000000201527是7 A1凯瑟琳狼A1 Niklas Luetzen A1 Hansjoerg桅杆A1尼科克雷默A1马可Reisert A1扫罗Beltran A1基督教Fung A1尤尔根•贝克A1霍斯特Urbach年2023 UL //www.ez-admanager.com/content/100/7/e651.abstract AB背景和目标自发颅内低血压(硅)的首页特点是脑脊液体积的损失。在这种情况下我们假设低体积更大的脑脊液流在上层脊柱和脊髓运动可以通过非侵入式测量相位对比MRI。方法前瞻性,年龄,性别,和身体质量指数(BMI)移植物控制在硅氮呈现患者脊柱纵向队列研究硬膜外的液体收集器(SLEC)进行了从2021年10月到2022年2月。Cardiac-gated 2 d相衬的MRI序列得到段C2和C3,脑脊液流和C5 / C6,脊髓运动分析。数据处理是完全自动化。脑脊液流动和脊髓运动分析峰振幅和每段总位移和心跳,分别。临床资料包括年龄、身高、体重指数、症状持续时间,伯尔尼分数据Dobrocky et al .,和类型的脊髓脑脊液漏Schievink et al。团体通过Mann-Whitney U测试比较;多元线性回归分析来解决可能的关系。结果20例患者与硅和40名健康对照组进行了分析;每组由70%的女性。 Eleven patients with SIH presented with type 1 leak, 8 with type 2, and 1 was indeterminate. CSF flow per heartbeat was increased at C2/C3 (peak-to-peak amplitude 65.68 ± 18.3 vs 42.50 ± 9.8 mm/s, total displacement 14.32 ± 3.5 vs 9.75 ± 2.7 mm, p < 0.001, respectively). Craniocaudal spinal cord motion per heartbeat was larger at segment C2/C3 (peak-to-peak amplitude 7.30 ± 2.4 vs 5.82 ± 2.0 mm/s, total displacement 1.01 ± 0.4 vs 0.74 ± 0.4 mm, p = 0.006, respectively) and at segment C5/C6 (total displacement 1.41 ± 0.7 vs 0.97 ± 0.4 mm, p = 0.021).Discussion SLEC-positive patients with SIH show higher CSF flow and higher spinal cord motion at the upper cervical spine. This increased craniocaudal motion of the spinal cord per heartbeat might produce increased mechanical strain on neural tissue and adherent structures, which may be a mechanism leading to cranial nerve dysfunction, neck pain, and stiffness in SIH. Noninvasive phase contrast MRI of CSF flow and spinal cord motion is a promising diagnostic tool in SIH.Trial Registration Information German Clinical Trials Register, identification number: DRKS00017351.Classification of Evidence This study provides Class III evidence that noninvasive phase contrast MRI of the upper spine identifies differences in CSF flow and spinal cord motion in patients with SIH compared with healthy controls.AUROC=area under the curve of receiver operating characteristic; BMI=body mass index; CNN=convolutional neural network; CSA=cross-sectional area; ICC=intraclass correlation coefficient; ICHD=International Classification of Headache Disorders; SIH=spontaneous intracranial hypotension; ROI=region of interest; SLEC=spinal longitudinal extradural fluid collection; VENC=velocity ENCoding (parameter)