TY -的T1 - CSF流和脊髓运动自发性颅内低血压患者JF -神经学乔-神经病学SP - e651 LP - e660做- 10.1212 / WNL。首页0000000000201527六世- 100 - 7 AU -凯瑟琳狼盟Niklas Luetzen盟Hansjoerg桅杆AU -尼科克雷默盟马可Reisert盟扫罗——非盟-基督教Fung AU -尤尔根•贝克AU -霍斯特Urbach Y1 - 2023/02/14 UR - //www.ez-admanager.com/content/100/7/e651.abstract N2 -背景和目标自发颅内低血压(硅)的特点是脑脊液体积的损失。首页在这种情况下我们假设低体积更大的脑脊液流在上层脊柱和脊髓运动可以通过非侵入式测量相位对比MRI。方法前瞻性,年龄,性别,和身体质量指数(BMI)移植物控制在硅氮呈现患者脊柱纵向队列研究硬膜外的液体收集器(SLEC)进行了从2021年10月到2022年2月。Cardiac-gated 2 d相衬的MRI序列得到段C2和C3,脑脊液流和C5 / C6,脊髓运动分析。数据处理是完全自动化。脑脊液流动和脊髓运动分析峰振幅和每段总位移和心跳,分别。临床资料包括年龄、身高、体重指数、症状持续时间,伯尔尼分数据Dobrocky et al .,和类型的脊髓脑脊液漏Schievink et al。团体通过Mann-Whitney U测试比较;多元线性回归分析来解决可能的关系。结果20例患者与硅和40名健康对照组进行了分析;每组由70%的女性。 Eleven patients with SIH presented with type 1 leak, 8 with type 2, and 1 was indeterminate. CSF flow per heartbeat was increased at C2/C3 (peak-to-peak amplitude 65.68 ± 18.3 vs 42.50 ± 9.8 mm/s, total displacement 14.32 ± 3.5 vs 9.75 ± 2.7 mm, p < 0.001, respectively). Craniocaudal spinal cord motion per heartbeat was larger at segment C2/C3 (peak-to-peak amplitude 7.30 ± 2.4 vs 5.82 ± 2.0 mm/s, total displacement 1.01 ± 0.4 vs 0.74 ± 0.4 mm, p = 0.006, respectively) and at segment C5/C6 (total displacement 1.41 ± 0.7 vs 0.97 ± 0.4 mm, p = 0.021).Discussion SLEC-positive patients with SIH show higher CSF flow and higher spinal cord motion at the upper cervical spine. This increased craniocaudal motion of the spinal cord per heartbeat might produce increased mechanical strain on neural tissue and adherent structures, which may be a mechanism leading to cranial nerve dysfunction, neck pain, and stiffness in SIH. Noninvasive phase contrast MRI of CSF flow and spinal cord motion is a promising diagnostic tool in SIH.Trial Registration Information German Clinical Trials Register, identification number: DRKS00017351.Classification of Evidence This study provides Class III evidence that noninvasive phase contrast MRI of the upper spine identifies differences in CSF flow and spinal cord motion in patients with SIH compared with healthy controls.AUROC=area under the curve of receiver operating characteristic; BMI=body mass index; CNN=convolutional neural network; CSA=cross-sectional area; ICC=intraclass correlation coefficient; ICHD=International Classification of Headache Disorders; SIH=spontaneous intracranial hypotension; ROI=region of interest; SLEC=spinal longitudinal extradural fluid collection; VENC=velocity ENCoding (parameter) ER -