TY -的T1 -等离子体在苏氨酸磷酸化τ181和神经精神症状的临床前和前驱的阿尔茨海默病JF -神经学乔-神经病学SP - e683 LP - e693做- 10.1212 / WNL。首页0000000000201517六世- 100 - 7盟Maryam Ghahremani AU -孟王盟庄志渊陈盟Henrik Zetterberg AU -埃里克史密斯盟Zahinoor伊斯梅尔AU -阿尔茨海默病的神经影像学的* Y1 - 2023/02/14 UR - //www.ez-admanager.com/content/100/7/e683.abstract N2 -等离子体背景和目标在苏氨酸磷酸化τ181 (p-tau181),经阿尔茨海默病(AD)首页病理变化的标志,可以更有效的方式来诊断广告比入侵或昂贵的生物标志物需要CSF或宠物。在某些个人、神经精神症状(NPS)是最早的广告表现形式,提前观察到清晰的认知能力下降。,然而,很少有研究评估广告生物标志物与NPS经常有不精确捕捉行为症状代表神经退行性疾病的后遗症。因此,轻度行为障碍(MBI)构建了框架NPS在某种程度上改善疾病的风险估计的精度。MBI核心标准规定,NPS新创出现在以后的生活和持续至少6个月。这里,横向比较和纵向,我们研究协会与p-tau181 MBI,神经心理测试性能和事件的广告。方法认知没有和轻度认知障碍(MCI)的阿尔茨海默病的神经影像学参与者被选中。MBI地位是来源于神经精神病学的库存(NPI)使用发表的算法。NPI总分在基线和第一年访问被用来实施MBI(分数在0在访问),NPS未满足MBI要求(NPS-not-MBI,分数在0仅1访问),而且没有NPS(得分= 0在访问)。线性回归是适合横断面分析; multilevel linear mixed-effects and Cox proportional hazards models were implemented to examine the longitudinal associations of MBI with changes in p-tau181 and cognition and incident dementia.Results The sample included 571 participants (age 72.2 years, 46.8% female, 64.8% MCI). Cross-sectionally (β = 8.1%, 95% CI 1.4%–15.2%, p = 0.02), MBI was associated with higher plasma p-tau181 levels compared with no NPS; NPS-not-MBI was not. Longitudinally, MBI was associated with higher p-tau181 (β = 0.014%, 95% CI 0.003–0.026, p = 0.02), in addition to a decline in memory and executive function. Survival analyses demonstrated a 3.92-fold greater dementia incidence in MBI, with no significant differences between NPS-not-MBI and no NPS.Discussion These findings extend the evidence base that MBI is associated with elevated risk of cognitive decline and dementia and a sequela of emerging Alzheimer-related proteinopathies. MBI offers a substantial improvement over current approaches that explore behavior as a proxy marker for Alzheimer-related proteinopathies, with both clinical and AD trial enrichment implications.Aβ=β-amyloid; AD=Alzheimer disease; ADNI=Alzheimer's Disease Neuroimaging Initiative; A/T/N=amyloid/tau/neurodegeneration; CU=cognitively unimpaired; HR=hazard ratio; MBI=mild behavioral impairment; MBI-C=MBI checklist; MLME=multilevel linear mixed effect; MMSE=Mini-Mental State Examination; NfL=neurofilament light; NIA-AA=National Institute of Aging–Alzheimer's Association; NPI=Neuropsychiatric Inventory; NPI-Q=NPI Questionnaire; NPS=neuropsychiatric symptoms; p-tau181=phosphorylated tau at threonine 181; RAVLT=Rey Auditory Verbal Learning Test ER -