TY -的T1 Pathway-Specific之间的中介效应的结构,功能,和运动损伤皮层下中风后摩根富林明-神经学乔-神经病学SP - e616 LP - e626做- 10.1212 / WNL。首页0000000000201495六世- 100 - 6盟Qiurong Yu盟Dazhi阴非盟-马库斯Kaiser盟Guojun徐AU -郭苗族盟风扇刘盟- Jianqi李盟Mingxia风扇Y1 - 2023/02/07 UR - //www.ez-admanager.com/content/100/6/e616.abstract N2 -背景和目的探讨pathway-首页specific对应焦皮层下结构和功能变化造成中风临床症状及其因果关系的影响。方法回顾,横断面研究中,我们主要集中在单方面的皮层下慢性中风患者moderate-severe运动损伤评估Fugl-Meyer评估(上肢)和健康对照组。所有的参与者进行了静息状态功能磁共振成像和扩散张量成像。解析pathway-specific结构共变,我们协会执行分析之间的细粒度的皮质脊髓束(花旗软件)来自6分区的感觉运动皮层和功能连通性(FC)相应的分区,以及精制胼胝体(CC)部分和两半球间的足球俱乐部。中介分析与FC中介被用来进一步评估pathway-specific结构性破坏对运动损伤的影响。结果35例患者(平均年龄52.7±10.2年,27人)和43个健康对照组(平均年龄56.2±9.3年,21人)登记。花旗软件6中,我们确定了9个结构上和功能上共变途径,来自ipsilesional初级运动区(M1),背运动前区(PMd),和初级躯体感觉皮层(p & lt;0.05,纠正)。FC的双边M1、PMd和腹侧前运动皮层与二级共变相应的CC部分变性(p & lt;0.05,纠正)。此外,这些共变结构和功能Fugl-Meyer评估有显著相关性(上肢)得分(p & lt; 0.05, uncorrected). In particular, FC between the ipsilesional PMd and contralesional cerebellum (β = −0.141, p < 0.05, CI = [−0.319 to −0.015]) and interhemispheric FC of the PMd (β = 0.169, p < 0.05, CI = [0.015–0.391]) showed significant mediation effects in the prediction of motor impairment with structural damage of the CST and CC.Discussions This study reveals causal influence of structural and functional pathways on motor impairment after subcortical stroke and provides a promising way to investigate pathway-specific structure-function coupling. Clinically, our findings may offer a circuit-based evidence for the PMd as a critical neuromodulation target in more impaired patients with stroke and also suggest the cerebellum as a potential target.CC=corpus callosum; contra-CB=contralesional cerebellum 8; CST=corticospinal tract; DTI=diffusion tensor imaging; FA=fractional anisotropy; FC=functional connectivity; FM-UE=Fugl-Meyer Assessment–Upper Extremity; FWE=familywise error; IPL=inferior parietal lobe; ipsi-PMd=ipsilesional dorsal premotor cortex; M1=primary motor cortex; MFG=middle frontal gyrus; MNI=Montreal Neurological Institute; PMd=dorsal premotor cortex; PMv=ventral premotor cortex; PoG=postcentral gyrus; preSMA=presupplementary motor area; S1=primary somatosensory cortex; SMA=supplementary motor area; SMATT=sensorimotor area tract template; SMC=sensorimotor cortex; TFCE=threshold-free cluster enhancement; TMS=transcranial magnetic stimulation; tDCS=transcranial current stimulation ER -