TY -的T1 -协会命名的区域萎缩减少原发性进行性失语JF -神经学乔-神经病学SP - e582 LP - e594做- 10.1212 / WNL。首页0000000000201491六世- 100 - 6盟邦尼l . Breining盟Andreia Vasconcellos法盟-克拉克多娜蒂盟梅丽莎黎明Stockbridge AU -艾琳·l·迈耶AU -布莱恩Caffo盟奥利维亚赫尔曼AU -朗达·弗里德曼盟-亚伦Meyer盟Kyrana Tsapkini AU - Argye伊丽莎白Hillis Y1 - 2023/02/07 UR - //www.ez-admanager.com/content/100/6/e582.abstract N2 -背景和目标原发性进行性失语(PPA)是一种神经退行性疾病,主要影响语言。首页大多数病灶萎缩如何影响语言的调查认为1时间点与健康对照组相比。然而,真正的萎缩量化需要比较个人的大脑。在这种观察性队列研究,我们确定了地区焦萎缩与同期下降命名在同一个人。方法横断面analyses-related波士顿命名测试(BNT)性能和体积在22个地区利益(roi)在每个时间点使用至少绝对收缩和选择算子(套索)回归。纵向分析评估BNT性能和体积变化的变化同样的roi。结果参与者(N = 62;50%的女性;平均年龄为66.8±7.4年)PPA完成了BNT和MRI两次(平均= 343.9±209.0天)。在横断面的左额下回pars opercularis,颞极、颞中回、颞下回被确定为命名的关键时间点。 Longitudinal analysis revealed that increasing atrophy in the left supramarginal gyrus and middle temporal pole predicted greater naming decline, as did female sex and longer intervals between time points.Discussion Although cross-sectional analyses identified classic language areas that were consistently related to poor performance at multiple time points, it was not increasing atrophy in these areas that lead to further decline: longitudinal analysis of each person's atrophy over time instead identified nearby but distinct regions where increased atrophy was related to decreasing performance. The results demonstrate that directly examining atrophy (in each individual) over time furthers understanding of decline in PPA and reveal the importance of left supramarginal gyrus and middle temporal pole in maintaining naming when areas normally critical for language degenerate. The novel results provide insight into how the underlying disease progresses to result in the clinical decline in naming, the deficit most common among all 3 PPA variants.BNT=Boston Naming Test; LASSO=Least Absolute Shrinkage and Selection Operator; NACC=National Alzheimer Coordinating Center; PALPA=Psycholinguistic Assessments of Language Processing in Aphasia; PPA=primary progressive aphasia; ROI=regions of interest ER -